Recombinant 4-1BB binding proteins and uses thereof
The present invention relates to recombinant binding proteins comprising a designed ankyrin repeat domain having binding specificity for 4-1 BB (CD137). Furthermore, the present invention relates to nucleic acids encoding such binding proteins, pharmaceutical compositions comprising such binding pro...
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| creator | LINKE ANDREAS HUPP JUERGEN LEVITSKY VIKTOR REICHEN CHRISTIAN |
| description | The present invention relates to recombinant binding proteins comprising a designed ankyrin repeat domain having binding specificity for 4-1 BB (CD137). Furthermore, the present invention relates to nucleic acids encoding such binding proteins, pharmaceutical compositions comprising such binding proteins or nucleic acids, and the use of such binding proteins, nucleic acids, or pharmaceutical compositions in the treatment of cells expressing 4-1 BB (e.g., in cells expressing 4-1 BB). The present invention relates to the activation of 4-1 BB in T lymphocytes (e.g., tumor localized T lymphocytes) and in methods for the treatment or diagnosis of diseases such as cancer in mammals, including humans.
本发明涉及包含对4-1 BB(CD137)具有结合特异性的经设计的锚蛋白重复结构域的重组结合蛋白。此外，本发明涉及编码此类结合蛋白的核酸、包含此类结合蛋白或核酸的药物组合物，以及此类结合蛋白、核酸或药物组合物在用于在表达4-1 BB的细胞(例如，肿瘤定位的T淋巴细胞)中活化4-1 BB和用于治疗或诊断包括人在内的哺乳动物中的疾病诸如癌症的方法中的用途。 |
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本发明涉及包含对4-1 BB(CD137)具有结合特异性的经设计的锚蛋白重复结构域的重组结合蛋白。此外，本发明涉及编码此类结合蛋白的核酸、包含此类结合蛋白或核酸的药物组合物，以及此类结合蛋白、核酸或药物组合物在用于在表达4-1 BB的细胞(例如，肿瘤定位的T淋巴细胞)中活化4-1 BB和用于治疗或诊断包括人在内的哺乳动物中的疾病诸如癌症的方法中的用途。</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220322&DB=EPODOC&CC=CN&NR=114222757A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220322&DB=EPODOC&CC=CN&NR=114222757A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LINKE ANDREAS</creatorcontrib><creatorcontrib>HUPP JUERGEN</creatorcontrib><creatorcontrib>LEVITSKY VIKTOR</creatorcontrib><creatorcontrib>REICHEN CHRISTIAN</creatorcontrib><title>Recombinant 4-1BB binding proteins and uses thereof</title><description>The present invention relates to recombinant binding proteins comprising a designed ankyrin repeat domain having binding specificity for 4-1 BB (CD137). Furthermore, the present invention relates to nucleic acids encoding such binding proteins, pharmaceutical compositions comprising such binding proteins or nucleic acids, and the use of such binding proteins, nucleic acids, or pharmaceutical compositions in the treatment of cells expressing 4-1 BB (e.g., in cells expressing 4-1 BB). The present invention relates to the activation of 4-1 BB in T lymphocytes (e.g., tumor localized T lymphocytes) and in methods for the treatment or diagnosis of diseases such as cancer in mammals, including humans.
本发明涉及包含对4-1 BB(CD137)具有结合特异性的经设计的锚蛋白重复结构域的重组结合蛋白。此外，本发明涉及编码此类结合蛋白的核酸、包含此类结合蛋白或核酸的药物组合物，以及此类结合蛋白、核酸或药物组合物在用于在表达4-1 BB的细胞(例如，肿瘤定位的T淋巴细胞)中活化4-1 BB和用于治疗或诊断包括人在内的哺乳动物中的疾病诸如癌症的方法中的用途。</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDAOSk3Oz03KzEvMK1Ew0TV0clIAclIy89IVCoryS1Iz84oVEvNSFEqLU4sVSjJSi1Lz03gYWNMSc4pTeaE0N4Oim2uIs4duakF-fGpxQWJyal5qSbyzn6GhiZGRkbmpuaMxMWoAkosrjw</recordid><startdate>20220322</startdate><enddate>20220322</enddate><creator>LINKE ANDREAS</creator><creator>HUPP JUERGEN</creator><creator>LEVITSKY VIKTOR</creator><creator>REICHEN CHRISTIAN</creator><scope>EVB</scope></search><sort><creationdate>20220322</creationdate><title>Recombinant 4-1BB binding proteins and uses thereof</title><author>LINKE ANDREAS ; HUPP JUERGEN ; LEVITSKY VIKTOR ; REICHEN CHRISTIAN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN114222757A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2022</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>LINKE ANDREAS</creatorcontrib><creatorcontrib>HUPP JUERGEN</creatorcontrib><creatorcontrib>LEVITSKY VIKTOR</creatorcontrib><creatorcontrib>REICHEN CHRISTIAN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LINKE ANDREAS</au><au>HUPP JUERGEN</au><au>LEVITSKY VIKTOR</au><au>REICHEN CHRISTIAN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Recombinant 4-1BB binding proteins and uses thereof</title><date>2022-03-22</date><risdate>2022</risdate><abstract>The present invention relates to recombinant binding proteins comprising a designed ankyrin repeat domain having binding specificity for 4-1 BB (CD137). Furthermore, the present invention relates to nucleic acids encoding such binding proteins, pharmaceutical compositions comprising such binding proteins or nucleic acids, and the use of such binding proteins, nucleic acids, or pharmaceutical compositions in the treatment of cells expressing 4-1 BB (e.g., in cells expressing 4-1 BB). The present invention relates to the activation of 4-1 BB in T lymphocytes (e.g., tumor localized T lymphocytes) and in methods for the treatment or diagnosis of diseases such as cancer in mammals, including humans.
本发明涉及包含对4-1 BB(CD137)具有结合特异性的经设计的锚蛋白重复结构域的重组结合蛋白。此外，本发明涉及编码此类结合蛋白的核酸、包含此类结合蛋白或核酸的药物组合物，以及此类结合蛋白、核酸或药物组合物在用于在表达4-1 BB的细胞(例如，肿瘤定位的T淋巴细胞)中活化4-1 BB和用于治疗或诊断包括人在内的哺乳动物中的疾病诸如癌症的方法中的用途。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | Recombinant 4-1BB binding proteins and uses thereof |
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