Pyrimidine compound containing thiophene as well as preparation method and application thereof

The invention provides thiophene-containing pyrimidine compounds as well as a preparation method and application thereof. The structural formula of the compounds is as follows: R1 is selected from CF3, CH3, Br, Cl and NO2; the thiophene-containing pyrimidine compound disclosed by the invention is novel in structure, has better water solubility, has a stronger inhibition effect on tumor cells, and has a very good application prospect in preparation of antitumor drugs. 本发明提供一种含噻吩的嘧啶类化合物其制备方法和应用，该类化合物的结构式为R1选自CF3、CH3、Br、Cl、NO2；R2选自本发明含噻吩的嘧啶类化合物结构新颖、具有较好的水溶性、对肿瘤细胞均具有较强的抑制作用，在制备抗肿瘤药物中具有很好的应用前景。