Uncaria-containing brain-targeting nano preparation and preparation method thereof

The invention discloses a brain-targeted nano preparation containing rhynchophylline, which is a nano preparation with a core-shell structure, which is prepared by taking 60%-gamma-PFGA as a core material of nanoparticles with the core-shell structure, taking PLA-SS-PEG-A2 as a shell material of nanoparticles with the core-shell structure, taking E-TPGS as a nonionic surfactant, and loading rhynchophylline or simultaneously loading rhynchophylline and Tariquilar. The brain-targeted nano preparation containing the rhynchophylline is small in particle size and stable in structure, has slow release and controlled release effects, overcomes the difficulty of low entrapment efficiency of the rhynchophylline, and improves the brain-targeted property of the rhynchophylline at the same time. 本发明公开了一种含钩藤碱的脑靶向纳米制剂，它是以60％-γ-PFGA为核壳结构纳米粒的核材料，以PLA-SS-PEG-A2为核壳结构纳米粒的壳材料，以E-TPGS为非离子表面活性剂，负载钩藤碱或同时负载钩藤碱与Tariquidar制备而成的具有核壳结构的纳米制剂。本发明含钩藤碱的脑靶向纳米制剂粒径小、结构稳定、具有缓释与控释作用，克服了钩藤碱包封率低的困难，同时提高了钩藤碱的脑靶向性。