Novel optionally substituted phenylimidazolidines, intermediates and process for prepn. thereof, use as drugs and pharmaceutical compositions contg. same

PCT No. PCT/FR95/00004 Sec. 371 Date Jun. 27, 1996 Sec. 102(e) Date Jun. 27, 1996 PCT Filed Jan. 4, 1995 PCT Pub. No. WO95/18794 PCT Pub. Date Jul. 13, 1995A compound in all possible racemic, enantiomeric and diastereoisomer forms of the formula wherein Y is -O-, Z2 is -CF3, Z1 is -CN or -NO2, X is...

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Hauptverfasser:	A. CLAUSSNER, F. GUBET, J.-G. TORSH
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Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator	A. CLAUSSNER F. GUBET J.-G. TORSH
description	PCT No. PCT/FR95/00004 Sec. 371 Date Jun. 27, 1996 Sec. 102(e) Date Jun. 27, 1996 PCT Filed Jan. 4, 1995 PCT Pub. No. WO95/18794 PCT Pub. Date Jul. 13, 1995A compound in all possible racemic, enantiomeric and diastereoisomer forms of the formula wherein Y is -O-, Z2 is -CF3, Z1 is -CN or -NO2, X is -O- or -S-, R3 is hydrogen or alkyl of 1 to 4 carbon atoms optionally substituted by at least one halogen or -CN and R4 and R5 are individually alkyl of 1 to 4 carbon atoms optionally substituted with a member of the group consisting of halogen, -OH, esterified or etherified or protected hydroxy and phenylthio optionally substituted by halogen or -OH, and wherein at least one of R4 and R5 is substituted having antiandrogenic activity.
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Date Jul. 13, 1995A compound in all possible racemic, enantiomeric and diastereoisomer forms of the formula wherein Y is -O-, Z2 is -CF3, Z1 is -CN or -NO2, X is -O- or -S-, R3 is hydrogen or alkyl of 1 to 4 carbon atoms optionally substituted by at least one halogen or -CN and R4 and R5 are individually alkyl of 1 to 4 carbon atoms optionally substituted with a member of the group consisting of halogen, -OH, esterified or etherified or protected hydroxy and phenylthio optionally substituted by halogen or -OH, and wherein at least one of R4 and R5 is substituted having antiandrogenic activity.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1997</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFjcFqAkEQRPeSgyR-g_0BRlgU7yJKTp5yl3an1m2YmR6mewLmT_K32YD3nOoVPKoW3c9FvxBJi4tmjvFB1m7m4s0RqEzIjyhJAn9rlCAZtibJjpoQhB1GnGev6gAzGrXOjJI35BMqdFxTMxAbhdruT3nimnhAcxk40qCpqMnfv80l-31Dxglv3cvI0bB85mu3Op8-jx_vKHqFlXkhw6_HS9_v-v22P2z_N34Bc_tTAw</recordid><startdate>19970129</startdate><enddate>19970129</enddate><creator>A. 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Date Jul. 13, 1995A compound in all possible racemic, enantiomeric and diastereoisomer forms of the formula wherein Y is -O-, Z2 is -CF3, Z1 is -CN or -NO2, X is -O- or -S-, R3 is hydrogen or alkyl of 1 to 4 carbon atoms optionally substituted by at least one halogen or -CN and R4 and R5 are individually alkyl of 1 to 4 carbon atoms optionally substituted with a member of the group consisting of halogen, -OH, esterified or etherified or protected hydroxy and phenylthio optionally substituted by halogen or -OH, and wherein at least one of R4 and R5 is substituted having antiandrogenic activity.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record>
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subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title	Novel optionally substituted phenylimidazolidines, intermediates and process for prepn. thereof, use as drugs and pharmaceutical compositions contg. same
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