Alkynyl-coupled difluorophenylamino pyridone HIV integrase inhibitor as well as preparation method and application thereof

The invention relates to the field of HIV virus resistance. Specifically, the invention relates to an HIV integrase inhibitor which is coupled through sonogashira and contains a 2, 4-difluorobenzene and aminopyridone structure, a preparation method of the HIV integrase inhibitor, and antiviral activity of the HIV integrase inhibitor in an in-vitro HIV pseudovirus of a tested compound. 本发明涉及HIV抗病毒领域。具体而言，本发明涉及一种通过sonogashira偶联的含2,4-二氟苯和氨基吡啶酮结构的HIV整合酶抑制剂、其制备方法及其在受试化合物体外HIV假病毒的抗病毒活性。