Manufacture of 1, 3-oxathiolane nucleosides

一种生产1,3-氧硫戊环核苷的方法,包括制备氧硫戊环环,随后将氧硫戊环与嘧啶和嘌呤碱缩合的有效方法。使用此处描述的方法,可以得到单独的对映体化合物。 Processes for the preparation of 1,3-oxathiolane nucleosides are provided that include efficient methods for the preparation of the 1,3-oxathiolane ring and subsequent condensation of the 1,3-oxathiolane with a pyrimidine or...

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Hauptverfasser: J.R. PAINTER, M. ALMOND, D.C. LIOTTA
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creator J.R. PAINTER
M. ALMOND
D.C. LIOTTA
description 一种生产1,3-氧硫戊环核苷的方法,包括制备氧硫戊环环,随后将氧硫戊环与嘧啶和嘌呤碱缩合的有效方法。使用此处描述的方法,可以得到单独的对映体化合物。 Processes for the preparation of 1,3-oxathiolane nucleosides are provided that include efficient methods for the preparation of the 1,3-oxathiolane ring and subsequent condensation of the 1,3-oxathiolane with a pyrimidine or purine base. Using the processes described herein, the compounds can be provided as isolated enantiomers.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title Manufacture of 1, 3-oxathiolane nucleosides
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