Preparation method of allopurinol

The invention provides a preparation process of allopurinol, which comprises the following steps: placing an allopurinol crude product in one or more organic solvents, and dissolving the allopurinol crude product; adding water mixed with an adsorbent, and filtering; and performing spray drying. The organic solvent is selected from the group consisting of ethanol, isopropanol, N, N-dimethylformamide, 1-methyl-2-pyrrolidone and/or dimethyl sulfoxide. 本发明提供了一种别嘌醇制备工艺，将别嘌醇粗品置于一种或多种有机溶剂中，将其溶解；加入混有吸附剂的水，过滤；喷雾干燥即得；所述有机溶剂选自乙醇、异丙醇、N,N-二甲基甲酰胺，1-甲基-2-吡咯烷酮和/或二甲基亚砜。