Application of 3-aryl benzofuran derivative EIE-2 in preparation of medicine for treating chronic obstructive pulmonary disease

Application of 3-aryl benzofuran derivative EIE-2 in preparation of medicine for treating chronic obstructive pulmonary disease

The invention belongs to the field of biological medicines, and discloses application of a 3-aryl benzofuran derivative EIE-2 shown in a formula (I) in preparation of a medicine for treating and/or preventing chronic obstructive pulmonary diseases. The 3-aryl benzofuran derivative EIE-2 disclosed by...

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Hauptverfasser: ZHANG ZIQIAN, SU FUBAO, YAO CHUNSUO, MA PEI, LI SHUYI, LI XUYU, HOU QI, LIN MINGBAO, FAN YIYAO, FAN YANNAN
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator ZHANG ZIQIAN
SU FUBAO
YAO CHUNSUO
MA PEI
LI SHUYI
LI XUYU
HOU QI
LIN MINGBAO
FAN YIYAO
FAN YANNAN
description The invention belongs to the field of biological medicines, and discloses application of a 3-aryl benzofuran derivative EIE-2 shown in a formula (I) in preparation of a medicine for treating and/or preventing chronic obstructive pulmonary diseases. The 3-aryl benzofuran derivative EIE-2 disclosed by the invention is simple in preparation method, has obvious anti-inflammatory activity, has an obvious treatment effect on chronic obstructive pulmonary diseases, has an improvement effect on pathological changes of lung tissue inflammation of a COPD (chronic obstructive pulmonary disease) model mouse, and can be used for preparing medicines for treating chronic obstructive pulmonary diseases. Various indexes of COPD airway inflammation can be improved, collection of the total number of leukocytes, neutrophil and macrophages in BALF is remarkably inhibited, the generation level of inflammatory factors TNF-alpha, IL-17A, IFN-gamma and the like in BALF is remarkably reduced, the compound can be applied to clinical tr
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Application of 3-aryl benzofuran derivative EIE-2 in preparation of medicine for treating chronic obstructive pulmonary disease
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