Sugammadex sodium related substance as well as preparation method and application thereof
The invention provides a sugammadex sodium related substance as well as a preparation method and application thereof. The method comprises the following steps: step a, reacting gamma-cyclodextrin with para-formaldehyde in an organic solvent containing iodine and a phosphorus-containing reagent to ob...
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| creator | QI HAOFEI YANG GUANG BAI JUNPENG HOU YUNZE WANG JINGYI HE XIAOXIA XIAO YU LIU HONGKAI GAO HONG WU LINGJING LI FAGUANG |
| description | The invention provides a sugammadex sodium related substance as well as a preparation method and application thereof. The method comprises the following steps: step a, reacting gamma-cyclodextrin with para-formaldehyde in an organic solvent containing iodine and a phosphorus-containing reagent to obtain an intermediate containing an intermediate impurity 1 and an intermediate impurity 2; and b, reacting the intermediate with 3-thio propionic acid in an organic solvent containing sodium alkali, and carrying out liquid phase separation to obtain the compounds shown in the formula I and the formula II. The compounds shown in the formula I and the formula II are necessities for quality control of sugammadex sodium, and can be used for content determination of sugammadex sodium, detection of impurities or related substances and quantitative control of the related substances.
本发明提供一种舒更葡糖钠有关物质及其制备方法和用途，所述的方法包括以下步骤：步骤a：γ-环糊精在含有碘和含磷试剂的有机溶剂中，与多聚甲醛反应得到含有中间体杂质1和中间体杂质2的中间体；步骤b：中间体与3-巯基丙酸在含有含钠碱的有机溶剂中反应，经液相分离，得到式I和式II化合物。本发 |
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本发明提供一种舒更葡糖钠有关物质及其制备方法和用途，所述的方法包括以下步骤：步骤a：γ-环糊精在含有碘和含磷试剂的有机溶剂中，与多聚甲醛反应得到含有中间体杂质1和中间体杂质2的中间体；步骤b：中间体与3-巯基丙酸在含有含钠碱的有机溶剂中反应，经液相分离，得到式I和式II化合物。本发</description><language>chi ; eng</language><subject>CHEMISTRY ; COMPOSITIONS BASED THEREON ; DERIVATIVES THEREOF ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; METALLURGY ; ORGANIC MACROMOLECULAR COMPOUNDS ; PHYSICS ; POLYSACCHARIDES ; TESTING ; THEIR PREPARATION OR CHEMICAL WORKING-UP</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220222&DB=EPODOC&CC=CN&NR=114075301A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220222&DB=EPODOC&CC=CN&NR=114075301A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>QI HAOFEI</creatorcontrib><creatorcontrib>YANG GUANG</creatorcontrib><creatorcontrib>BAI JUNPENG</creatorcontrib><creatorcontrib>HOU YUNZE</creatorcontrib><creatorcontrib>WANG JINGYI</creatorcontrib><creatorcontrib>HE XIAOXIA</creatorcontrib><creatorcontrib>XIAO YU</creatorcontrib><creatorcontrib>LIU HONGKAI</creatorcontrib><creatorcontrib>GAO HONG</creatorcontrib><creatorcontrib>WU LINGJING</creatorcontrib><creatorcontrib>LI FAGUANG</creatorcontrib><title>Sugammadex sodium related substance as well as preparation method and application thereof</title><description>The invention provides a sugammadex sodium related substance as well as a preparation method and application thereof. The method comprises the following steps: step a, reacting gamma-cyclodextrin with para-formaldehyde in an organic solvent containing iodine and a phosphorus-containing reagent to obtain an intermediate containing an intermediate impurity 1 and an intermediate impurity 2; and b, reacting the intermediate with 3-thio propionic acid in an organic solvent containing sodium alkali, and carrying out liquid phase separation to obtain the compounds shown in the formula I and the formula II. The compounds shown in the formula I and the formula II are necessities for quality control of sugammadex sodium, and can be used for content determination of sugammadex sodium, detection of impurities or related substances and quantitative control of the related substances.
本发明提供一种舒更葡糖钠有关物质及其制备方法和用途，所述的方法包括以下步骤：步骤a：γ-环糊精在含有碘和含磷试剂的有机溶剂中，与多聚甲醛反应得到含有中间体杂质1和中间体杂质2的中间体；步骤b：中间体与3-巯基丙酸在含有含钠碱的有机溶剂中反应，经液相分离，得到式I和式II化合物。本发</description><subject>CHEMISTRY</subject><subject>COMPOSITIONS BASED THEREON</subject><subject>DERIVATIVES THEREOF</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>METALLURGY</subject><subject>ORGANIC MACROMOLECULAR COMPOUNDS</subject><subject>PHYSICS</subject><subject>POLYSACCHARIDES</subject><subject>TESTING</subject><subject>THEIR PREPARATION OR CHEMICAL WORKING-UP</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNijsKAjEYBtNYiHqH3wMIG1axlkWxstHGavlNvnUDeZEHenwVPYDFMDDMVFzP9c7OscaTctCmOkqwXKAp11su7BWIMz1g7ccxIXLiYoInhzIGTezfxGiN-uYyIiEMczEZ2GYsfp6J5WF_6Y4rxNAjR1bwKH13knLdbDdtI3ftP88LHNY7CA</recordid><startdate>20220222</startdate><enddate>20220222</enddate><creator>QI HAOFEI</creator><creator>YANG GUANG</creator><creator>BAI JUNPENG</creator><creator>HOU YUNZE</creator><creator>WANG JINGYI</creator><creator>HE XIAOXIA</creator><creator>XIAO YU</creator><creator>LIU HONGKAI</creator><creator>GAO HONG</creator><creator>WU LINGJING</creator><creator>LI FAGUANG</creator><scope>EVB</scope></search><sort><creationdate>20220222</creationdate><title>Sugammadex sodium related substance as well as preparation method and application thereof</title><author>QI HAOFEI ; YANG GUANG ; BAI JUNPENG ; HOU YUNZE ; WANG JINGYI ; HE XIAOXIA ; XIAO YU ; LIU HONGKAI ; GAO HONG ; WU LINGJING ; LI FAGUANG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN114075301A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2022</creationdate><topic>CHEMISTRY</topic><topic>COMPOSITIONS BASED THEREON</topic><topic>DERIVATIVES THEREOF</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>METALLURGY</topic><topic>ORGANIC MACROMOLECULAR COMPOUNDS</topic><topic>PHYSICS</topic><topic>POLYSACCHARIDES</topic><topic>TESTING</topic><topic>THEIR PREPARATION OR CHEMICAL WORKING-UP</topic><toplevel>online_resources</toplevel><creatorcontrib>QI HAOFEI</creatorcontrib><creatorcontrib>YANG GUANG</creatorcontrib><creatorcontrib>BAI JUNPENG</creatorcontrib><creatorcontrib>HOU YUNZE</creatorcontrib><creatorcontrib>WANG JINGYI</creatorcontrib><creatorcontrib>HE XIAOXIA</creatorcontrib><creatorcontrib>XIAO YU</creatorcontrib><creatorcontrib>LIU HONGKAI</creatorcontrib><creatorcontrib>GAO HONG</creatorcontrib><creatorcontrib>WU LINGJING</creatorcontrib><creatorcontrib>LI FAGUANG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>QI HAOFEI</au><au>YANG GUANG</au><au>BAI JUNPENG</au><au>HOU YUNZE</au><au>WANG JINGYI</au><au>HE XIAOXIA</au><au>XIAO YU</au><au>LIU HONGKAI</au><au>GAO HONG</au><au>WU LINGJING</au><au>LI FAGUANG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Sugammadex sodium related substance as well as preparation method and application thereof</title><date>2022-02-22</date><risdate>2022</risdate><abstract>The invention provides a sugammadex sodium related substance as well as a preparation method and application thereof. The method comprises the following steps: step a, reacting gamma-cyclodextrin with para-formaldehyde in an organic solvent containing iodine and a phosphorus-containing reagent to obtain an intermediate containing an intermediate impurity 1 and an intermediate impurity 2; and b, reacting the intermediate with 3-thio propionic acid in an organic solvent containing sodium alkali, and carrying out liquid phase separation to obtain the compounds shown in the formula I and the formula II. The compounds shown in the formula I and the formula II are necessities for quality control of sugammadex sodium, and can be used for content determination of sugammadex sodium, detection of impurities or related substances and quantitative control of the related substances.
本发明提供一种舒更葡糖钠有关物质及其制备方法和用途，所述的方法包括以下步骤：步骤a：γ-环糊精在含有碘和含磷试剂的有机溶剂中，与多聚甲醛反应得到含有中间体杂质1和中间体杂质2的中间体；步骤b：中间体与3-巯基丙酸在含有含钠碱的有机溶剂中反应，经液相分离，得到式I和式II化合物。本发</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY COMPOSITIONS BASED THEREON DERIVATIVES THEREOF INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS PHYSICS POLYSACCHARIDES TESTING THEIR PREPARATION OR CHEMICAL WORKING-UP |
| title | Sugammadex sodium related substance as well as preparation method and application thereof |
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