Preparation method of hydrocortisone

The invention relates to the technical field of pharmacy, and discloses a preparation method of hydrocortisone. The method comprises the following steps: by taking a hydrocortisone acetate crude product as an initial raw material, carrying out a pypocholoride impurity removal reaction and an IRA-400 resin hydrolysis reaction to prepare the hydrocortisone. According to the preparation method, generation of impurities in the reaction process is reduced through a pypocholoride impurity removal reaction step matched with resin hydrolysis treatment, use of iodine which is high in toxicity and unfriendly to the environment is avoided, pollution to the environment is reduced, athe method is easy and convenient to operate, and suitable for industrial production, and the obtained product is high in yield (the total mass yield is higher than 75%) and high in purity (higher than 99.5%), and has a wide market prospect. 本发明涉及制药技术领域，本发明公开了一种氢化可的松的制备方法，本发明方法以醋酸氢化可的松粗品为起始原料，经次氯酸盐除杂反应、IRA-400树脂水解反应两个步骤，制备得到氢化可的松。本发明制备方法通过次氯酸盐