Chalcone derivative, preparation thereof and application of chalcone derivative in preparation of antitumor drugs or functional food
The invention discloses a chalcone derivative, preparation thereof and application of the chalcone derivative in preparation of antitumor drugs or functional food. The chalcone derivative is prepared by the following steps: performing ethanol reflux extraction on dried Ranunculus laetus to obtain a...
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| creator | HIDAYAT HUSSEIN WANG XIAO CUI LI LIU JIE IFTIKHAR ALI SUN RONG PIAO ZHENGYI WANG DAIJIE CAO GUIYUN JIANG YUJUAN |
| description | The invention discloses a chalcone derivative, preparation thereof and application of the chalcone derivative in preparation of antitumor drugs or functional food. The chalcone derivative is prepared by the following steps: performing ethanol reflux extraction on dried Ranunculus laetus to obtain a crude extract; carrying out silica gel column chromatography on the crude extract, and carrying out gradient elution by adopting an n-hexane-ethyl acetate elution system; carrying out secondary chromatographic separation on the fourth fraction n-hexane-ethyl acetate solvent system on a silica gel filler to obtain a compound 1 and a compound 2; and carrying out secondary chromatographic separation on the fifth fraction on a silica gel filler by adopting an n-hexane-ethyl acetate solvent system to obtain a compound 3, a compound 4 and a compound 5. A foundation is laid for further research and application of Ranunculus laetus.
本发明公开了一种查尔酮衍生物及其制备和在制备抗肿瘤药物或功能食品中的应用，将干燥黄毛茛进行乙醇回流提取，得粗提物；将粗提物进行硅胶柱色谱层析，采用正己烷-乙酸乙酯洗脱体系梯度洗脱；将 |
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本发明公开了一种查尔酮衍生物及其制备和在制备抗肿瘤药物或功能食品中的应用，将干燥黄毛茛进行乙醇回流提取，得粗提物；将粗提物进行硅胶柱色谱层析，采用正己烷-乙酸乙酯洗脱体系梯度洗脱；将</description><language>chi ; eng</language><subject>CHEMISTRY ; FOODS OR FOODSTUFFS ; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT ; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220211&DB=EPODOC&CC=CN&NR=114031592A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220211&DB=EPODOC&CC=CN&NR=114031592A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HIDAYAT HUSSEIN</creatorcontrib><creatorcontrib>WANG XIAO</creatorcontrib><creatorcontrib>CUI LI</creatorcontrib><creatorcontrib>LIU JIE</creatorcontrib><creatorcontrib>IFTIKHAR ALI</creatorcontrib><creatorcontrib>SUN RONG</creatorcontrib><creatorcontrib>PIAO ZHENGYI</creatorcontrib><creatorcontrib>WANG DAIJIE</creatorcontrib><creatorcontrib>CAO GUIYUN</creatorcontrib><creatorcontrib>JIANG YUJUAN</creatorcontrib><title>Chalcone derivative, preparation thereof and application of chalcone derivative in preparation of antitumor drugs or functional food</title><description>The invention discloses a chalcone derivative, preparation thereof and application of the chalcone derivative in preparation of antitumor drugs or functional food. The chalcone derivative is prepared by the following steps: performing ethanol reflux extraction on dried Ranunculus laetus to obtain a crude extract; carrying out silica gel column chromatography on the crude extract, and carrying out gradient elution by adopting an n-hexane-ethyl acetate elution system; carrying out secondary chromatographic separation on the fourth fraction n-hexane-ethyl acetate solvent system on a silica gel filler to obtain a compound 1 and a compound 2; and carrying out secondary chromatographic separation on the fifth fraction on a silica gel filler by adopting an n-hexane-ethyl acetate solvent system to obtain a compound 3, a compound 4 and a compound 5. A foundation is laid for further research and application of Ranunculus laetus.
本发明公开了一种查尔酮衍生物及其制备和在制备抗肿瘤药物或功能食品中的应用，将干燥黄毛茛进行乙醇回流提取，得粗提物；将粗提物进行硅胶柱色谱层析，采用正己烷-乙酸乙酯洗脱体系梯度洗脱；将</description><subject>CHEMISTRY</subject><subject>FOODS OR FOODSTUFFS</subject><subject>FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT</subject><subject>THEIR TREATMENT, NOT COVERED BY OTHER CLASSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNi7kKAjEQhtNYiPoOY6_gulpYSlCsrOyXIZm4gZgJOfYJfHDj0YiN1X9-Y3GXPTrFnkBTtANmO9ACQqSAsQb2kHuKxAbQa8AQnFXvvlbqlwXrv-gXmG0uN46gY7kmqMYUr54zOjDMeipGBl2i2UcnYn48XORpSYE7SgEVecqdPDfNZtU229163_7zeQD-sEuO</recordid><startdate>20220211</startdate><enddate>20220211</enddate><creator>HIDAYAT HUSSEIN</creator><creator>WANG XIAO</creator><creator>CUI LI</creator><creator>LIU JIE</creator><creator>IFTIKHAR ALI</creator><creator>SUN RONG</creator><creator>PIAO ZHENGYI</creator><creator>WANG DAIJIE</creator><creator>CAO GUIYUN</creator><creator>JIANG YUJUAN</creator><scope>EVB</scope></search><sort><creationdate>20220211</creationdate><title>Chalcone derivative, preparation thereof and application of chalcone derivative in preparation of antitumor drugs or functional food</title><author>HIDAYAT HUSSEIN ; WANG XIAO ; CUI LI ; LIU JIE ; IFTIKHAR ALI ; SUN RONG ; PIAO ZHENGYI ; WANG DAIJIE ; CAO GUIYUN ; JIANG YUJUAN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN114031592A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2022</creationdate><topic>CHEMISTRY</topic><topic>FOODS OR FOODSTUFFS</topic><topic>FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT</topic><topic>THEIR TREATMENT, NOT COVERED BY OTHER CLASSES</topic><toplevel>online_resources</toplevel><creatorcontrib>HIDAYAT HUSSEIN</creatorcontrib><creatorcontrib>WANG XIAO</creatorcontrib><creatorcontrib>CUI LI</creatorcontrib><creatorcontrib>LIU JIE</creatorcontrib><creatorcontrib>IFTIKHAR ALI</creatorcontrib><creatorcontrib>SUN RONG</creatorcontrib><creatorcontrib>PIAO ZHENGYI</creatorcontrib><creatorcontrib>WANG DAIJIE</creatorcontrib><creatorcontrib>CAO GUIYUN</creatorcontrib><creatorcontrib>JIANG YUJUAN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HIDAYAT HUSSEIN</au><au>WANG XIAO</au><au>CUI LI</au><au>LIU JIE</au><au>IFTIKHAR ALI</au><au>SUN RONG</au><au>PIAO ZHENGYI</au><au>WANG DAIJIE</au><au>CAO GUIYUN</au><au>JIANG YUJUAN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Chalcone derivative, preparation thereof and application of chalcone derivative in preparation of antitumor drugs or functional food</title><date>2022-02-11</date><risdate>2022</risdate><abstract>The invention discloses a chalcone derivative, preparation thereof and application of the chalcone derivative in preparation of antitumor drugs or functional food. The chalcone derivative is prepared by the following steps: performing ethanol reflux extraction on dried Ranunculus laetus to obtain a crude extract; carrying out silica gel column chromatography on the crude extract, and carrying out gradient elution by adopting an n-hexane-ethyl acetate elution system; carrying out secondary chromatographic separation on the fourth fraction n-hexane-ethyl acetate solvent system on a silica gel filler to obtain a compound 1 and a compound 2; and carrying out secondary chromatographic separation on the fifth fraction on a silica gel filler by adopting an n-hexane-ethyl acetate solvent system to obtain a compound 3, a compound 4 and a compound 5. A foundation is laid for further research and application of Ranunculus laetus.
本发明公开了一种查尔酮衍生物及其制备和在制备抗肿瘤药物或功能食品中的应用，将干燥黄毛茛进行乙醇回流提取，得粗提物；将粗提物进行硅胶柱色谱层析，采用正己烷-乙酸乙酯洗脱体系梯度洗脱；将</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES |
| title | Chalcone derivative, preparation thereof and application of chalcone derivative in preparation of antitumor drugs or functional food |
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