Bispecific T cell agonist CD3-FAP/nanoBiTE, preparation and application thereof in tumor resistance

The present invention relates to a polypeptide comprising a bispecific T cell agonist CD3-FAP/nanoBiTE, a polynucleotide encoding the polypeptide, a preparation method of the polypeptide and polynucleotide, and application of the polypeptide. The bispecific T cell agonist CD3-FAP/nano BiTE is a nove...

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Bibliographische Detailangaben
Hauptverfasser:	XIE SHENXIA, YANG XIAOMEI, LI CUI, LU XIAOLING, SHI WEI
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to a polypeptide comprising a bispecific T cell agonist CD3-FAP/nanoBiTE, a polynucleotide encoding the polypeptide, a preparation method of the polypeptide and polynucleotide, and application of the polypeptide. The bispecific T cell agonist CD3-FAP/nano BiTE is a novel bispecific T cell engager (BiTE)-CD3-FAP/nano BiTE based on a nano antibody, the bispecific T cell agonist CD3-FAP/nano BiTE induces T cells to target tumor cells, so that the tumor resistant effect is exerted, and a new strategy is provided for tumor cell immune targeted therapy of BiTE. 本发明涉及包含双特异性T细胞激动剂CD3-FAP/nanoBiTE的多肽，编码该多肽的多核苷酸，所述多肽和多核苷酸的制备方法，及其应用。所述双特异性T细胞激动剂CD3-FAP/nanoBiTE是基于纳米抗体的新型双特异性T细胞激动剂(bispecific T cell engager，BiTE)-CD3-FAP/nanoBiTE，其诱导T细胞靶向肿瘤细胞，发挥抗肿瘤效应，为BiTE的肿瘤细胞免疫靶向治疗提供一种新的策略。