COMPOSITION FOR TISSUE REGENERATION, METHOD OF PRODUCTION AND USES THEREOF
The invention describes a method for obtaining a composition for tissue regeneration, comprising the following steps: providing M2-macrophages, co-culturing the M2-macrophages with tissue-specific cells in serum free medium; and collecting the supernatant of the co-culture. The compositions obtained...
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| creator | BLAZQUEZ MARTINEZ ALEJANDRO DESPORTE BIELSA PAULA DE GREGORIO JUAN CARLOS FERNANDEZ VICENTE PABLO LAPUENTE FERNANDEZ JUAN PEDRO CAYUELA CALVO MARIA DOS ANJOS VILABOA SEVERIANO IGLESIAS MORENO CARMEN GOMEZ CEPA GONZALO SANZ MORENO JARA |
| description | The invention describes a method for obtaining a composition for tissue regeneration, comprising the following steps: providing M2-macrophages, co-culturing the M2-macrophages with tissue-specific cells in serum free medium; and collecting the supernatant of the co-culture. The compositions obtained by this method are suitable in medicine regenerative treatments, since are able to regenerate injured tissue. These products are sterile cell-free physiological aqueous solutions that show specific tissue concentration patterns to provide optimal tissue-specific regenerative effects. The compositions of the invention may be stored for long periods cryopreserved or lyophilized until its use, avoiding any subsequent blood extraction from the cell-donor, being the stored growth factors and/or cytokines biologically active after long-term storage. Moreover, the compositions may be potentially applied in both autologous and allogenic treatments.
本发明描述了获得用于组织再生的组合物的方法，其包括以下步骤：提供M2型巨噬细胞，在无血清培养基中将M2型巨噬细胞与组织特异性细胞共培养；并收集共培养 |
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本发明描述了获得用于组织再生的组合物的方法，其包括以下步骤：提供M2型巨噬细胞，在无血清培养基中将M2型巨噬细胞与组织特异性细胞共培养；并收集共培养</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20211221&DB=EPODOC&CC=CN&NR=113825833A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76418</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20211221&DB=EPODOC&CC=CN&NR=113825833A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BLAZQUEZ MARTINEZ ALEJANDRO</creatorcontrib><creatorcontrib>DESPORTE BIELSA PAULA</creatorcontrib><creatorcontrib>DE GREGORIO JUAN CARLOS</creatorcontrib><creatorcontrib>FERNANDEZ VICENTE PABLO</creatorcontrib><creatorcontrib>LAPUENTE FERNANDEZ JUAN PEDRO</creatorcontrib><creatorcontrib>CAYUELA CALVO MARIA</creatorcontrib><creatorcontrib>DOS ANJOS VILABOA SEVERIANO</creatorcontrib><creatorcontrib>IGLESIAS MORENO CARMEN</creatorcontrib><creatorcontrib>GOMEZ CEPA GONZALO</creatorcontrib><creatorcontrib>SANZ MORENO JARA</creatorcontrib><title>COMPOSITION FOR TISSUE REGENERATION, METHOD OF PRODUCTION AND USES THEREOF</title><description>The invention describes a method for obtaining a composition for tissue regeneration, comprising the following steps: providing M2-macrophages, co-culturing the M2-macrophages with tissue-specific cells in serum free medium; and collecting the supernatant of the co-culture. The compositions obtained by this method are suitable in medicine regenerative treatments, since are able to regenerate injured tissue. These products are sterile cell-free physiological aqueous solutions that show specific tissue concentration patterns to provide optimal tissue-specific regenerative effects. The compositions of the invention may be stored for long periods cryopreserved or lyophilized until its use, avoiding any subsequent blood extraction from the cell-donor, being the stored growth factors and/or cytokines biologically active after long-term storage. Moreover, the compositions may be potentially applied in both autologous and allogenic treatments.
本发明描述了获得用于组织再生的组合物的方法，其包括以下步骤：提供M2型巨噬细胞，在无血清培养基中将M2型巨噬细胞与组织特异性细胞共培养；并收集共培养</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPBy9vcN8A_2DPH091Nw8w9SCPEMDg51VQhydXf1cw1yBInrKPi6hnj4uyj4uykEBPm7hDqDVTv6uSiEBrsGK4R4uAa5-rvxMLCmJeYUp_JCaW4GRTfXEGcP3dSC_PjU4oLE5NS81JJ4Zz9DQ2MLI1MLY2NHY2LUAACAkC2Z</recordid><startdate>20211221</startdate><enddate>20211221</enddate><creator>BLAZQUEZ MARTINEZ ALEJANDRO</creator><creator>DESPORTE BIELSA PAULA</creator><creator>DE GREGORIO JUAN CARLOS</creator><creator>FERNANDEZ VICENTE PABLO</creator><creator>LAPUENTE FERNANDEZ JUAN PEDRO</creator><creator>CAYUELA CALVO MARIA</creator><creator>DOS ANJOS VILABOA SEVERIANO</creator><creator>IGLESIAS MORENO CARMEN</creator><creator>GOMEZ CEPA GONZALO</creator><creator>SANZ MORENO JARA</creator><scope>EVB</scope></search><sort><creationdate>20211221</creationdate><title>COMPOSITION FOR TISSUE REGENERATION, METHOD OF PRODUCTION AND USES THEREOF</title><author>BLAZQUEZ MARTINEZ ALEJANDRO ; DESPORTE BIELSA PAULA ; DE GREGORIO JUAN CARLOS ; FERNANDEZ VICENTE PABLO ; LAPUENTE FERNANDEZ JUAN PEDRO ; CAYUELA CALVO MARIA ; DOS ANJOS VILABOA SEVERIANO ; IGLESIAS MORENO CARMEN ; GOMEZ CEPA GONZALO ; SANZ MORENO JARA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN113825833A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2021</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>BLAZQUEZ MARTINEZ ALEJANDRO</creatorcontrib><creatorcontrib>DESPORTE BIELSA PAULA</creatorcontrib><creatorcontrib>DE GREGORIO JUAN CARLOS</creatorcontrib><creatorcontrib>FERNANDEZ VICENTE PABLO</creatorcontrib><creatorcontrib>LAPUENTE FERNANDEZ JUAN PEDRO</creatorcontrib><creatorcontrib>CAYUELA CALVO MARIA</creatorcontrib><creatorcontrib>DOS ANJOS VILABOA SEVERIANO</creatorcontrib><creatorcontrib>IGLESIAS MORENO CARMEN</creatorcontrib><creatorcontrib>GOMEZ CEPA GONZALO</creatorcontrib><creatorcontrib>SANZ MORENO JARA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BLAZQUEZ MARTINEZ ALEJANDRO</au><au>DESPORTE BIELSA PAULA</au><au>DE GREGORIO JUAN CARLOS</au><au>FERNANDEZ VICENTE PABLO</au><au>LAPUENTE FERNANDEZ JUAN PEDRO</au><au>CAYUELA CALVO MARIA</au><au>DOS ANJOS VILABOA SEVERIANO</au><au>IGLESIAS MORENO CARMEN</au><au>GOMEZ CEPA GONZALO</au><au>SANZ MORENO JARA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>COMPOSITION FOR TISSUE REGENERATION, METHOD OF PRODUCTION AND USES THEREOF</title><date>2021-12-21</date><risdate>2021</risdate><abstract>The invention describes a method for obtaining a composition for tissue regeneration, comprising the following steps: providing M2-macrophages, co-culturing the M2-macrophages with tissue-specific cells in serum free medium; and collecting the supernatant of the co-culture. The compositions obtained by this method are suitable in medicine regenerative treatments, since are able to regenerate injured tissue. These products are sterile cell-free physiological aqueous solutions that show specific tissue concentration patterns to provide optimal tissue-specific regenerative effects. The compositions of the invention may be stored for long periods cryopreserved or lyophilized until its use, avoiding any subsequent blood extraction from the cell-donor, being the stored growth factors and/or cytokines biologically active after long-term storage. Moreover, the compositions may be potentially applied in both autologous and allogenic treatments.
本发明描述了获得用于组织再生的组合物的方法，其包括以下步骤：提供M2型巨噬细胞，在无血清培养基中将M2型巨噬细胞与组织特异性细胞共培养；并收集共培养</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | COMPOSITION FOR TISSUE REGENERATION, METHOD OF PRODUCTION AND USES THEREOF |
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