Preparation method of 2-fluoro-3-trifluoromethylpyridine

The invention belongs to the technical field of chemical synthesis, and particularly relates to a preparation method of 2-fluoro-3-trifluoromethylpyridine. According to the method, 2, 5-dichloro-3-trifluoromethylpyridine is used as a raw material, and is converted into 2-fluoro-3-trifluoromethylpyri...

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Bibliographische Detailangaben
Hauptverfasser: ZHANG ZUOSHAN, LIU JUN, SUN QIXIA, XU YUMEI, DONG WENKAI, JIANG AIZHONG, LIU QINSHENG, XIAO CAIGEN, LI LEI
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention belongs to the technical field of chemical synthesis, and particularly relates to a preparation method of 2-fluoro-3-trifluoromethylpyridine. According to the method, 2, 5-dichloro-3-trifluoromethylpyridine is used as a raw material, and is converted into 2-fluoro-3-trifluoromethylpyridine through directional fluorination and selective hydrogenation reduction dechlorination. The 2, 5-dichloro-3-trifluoromethylpyridine is a derivative of a main byproduct obtained by excessive chlorination in the production process of the 2, 3-dichloro-5-trifluoromethylpyridine and belongs to wastes, so that the preparation process of the 2-fluoro-3-trifluoromethylpyridine has the advantages of easily available raw materials and low cost, meanwhile, the reaction process is simple in condition, and high-yield preparation of the 2, 3-dichloro-5-trifluoromethylpyridine is realized. 本发明属于化工合成技术领域,具体涉及一种2-氟-3-三氟甲基吡啶的制备方法。所述方法以2,5-二氯-3-三氟甲基吡啶为原料,经定向氟化和选择性加氢还原脱氯,转化为2-氟-3-三氟甲基吡啶。而2,5-二氯-3-三氟甲基吡啶是在2,3-二氯-5-三氟甲基吡啶生产过程中因过度氯化