Bis (2, 4-dichlorophenethyl) amine hydrochloride and preparation method thereof
The invention belongs to the technical field of organic synthesis, and particularly relates to bis (2, 4-dichlorophenethyl) amine hydrochloride and a preparation method thereof. The structural formula of the bis (2, 4-dichlorophenethyl) amine hydrochloride is shown in the specification, and the 1H N...
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| creator | ZHENG GUANGBING LI JIAN HOU WEI GOU GUOFENG TIAN CHAO |
| description | The invention belongs to the technical field of organic synthesis, and particularly relates to bis (2, 4-dichlorophenethyl) amine hydrochloride and a preparation method thereof. The structural formula of the bis (2, 4-dichlorophenethyl) amine hydrochloride is shown in the specification, and the 1H NMR spectrum parameters of the compound are as follows: 1H NMR (600MHz, (CD3) 2SO) delta 9.22 (s, 1H), 7.65 (s, 1H), 7.45 (d, 2H), 3.14-3.18 (t, 2H) and 3.09-3.13 (t, 2H). The preparation method comprises the following steps: adding 2, 4-dichlorophenylacetonitrile into an organic solvent, adding a catalyst, introducing hydrogen for reaction, and performing post-treatment to obtain the bis (2, 4-dichlorophenethyl) amine hydrochloride. The method has important significance on quality control of 2, 4-dichlorophenylethylamine, the steps are short, the raw materials are easy to obtain, and the product is high in yield and purity.
本发明属于有机合成技术领域，具体涉及一种双(2,4-二氯苯乙基)胺盐酸盐及其制备方法。所述的双(2,4-二氯苯乙基)胺盐酸盐，该化合物的结构式如下：该化合物的1H NMR图谱参数为：1 |
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本发明属于有机合成技术领域，具体涉及一种双(2,4-二氯苯乙基)胺盐酸盐及其制备方法。所述的双(2,4-二氯苯乙基)胺盐酸盐，该化合物的结构式如下：该化合物的1H NMR图谱参数为：1</description><language>chi ; eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY ; CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY ; PERFORMING OPERATIONS ; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL ; THEIR RELEVANT APPARATUS ; TRANSPORTING</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20211203&DB=EPODOC&CC=CN&NR=113735715A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76517</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20211203&DB=EPODOC&CC=CN&NR=113735715A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ZHENG GUANGBING</creatorcontrib><creatorcontrib>LI JIAN</creatorcontrib><creatorcontrib>HOU WEI</creatorcontrib><creatorcontrib>GOU GUOFENG</creatorcontrib><creatorcontrib>TIAN CHAO</creatorcontrib><title>Bis (2, 4-dichlorophenethyl) amine hydrochloride and preparation method thereof</title><description>The invention belongs to the technical field of organic synthesis, and particularly relates to bis (2, 4-dichlorophenethyl) amine hydrochloride and a preparation method thereof. The structural formula of the bis (2, 4-dichlorophenethyl) amine hydrochloride is shown in the specification, and the 1H NMR spectrum parameters of the compound are as follows: 1H NMR (600MHz, (CD3) 2SO) delta 9.22 (s, 1H), 7.65 (s, 1H), 7.45 (d, 2H), 3.14-3.18 (t, 2H) and 3.09-3.13 (t, 2H). The preparation method comprises the following steps: adding 2, 4-dichlorophenylacetonitrile into an organic solvent, adding a catalyst, introducing hydrogen for reaction, and performing post-treatment to obtain the bis (2, 4-dichlorophenethyl) amine hydrochloride. The method has important significance on quality control of 2, 4-dichlorophenylethylamine, the steps are short, the raw materials are easy to obtain, and the product is high in yield and purity.
本发明属于有机合成技术领域，具体涉及一种双(2,4-二氯苯乙基)胺盐酸盐及其制备方法。所述的双(2,4-二氯苯乙基)胺盐酸盐，该化合物的结构式如下：该化合物的1H NMR图谱参数为：1</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PERFORMING OPERATIONS</subject><subject>PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL</subject><subject>THEIR RELEVANT APPARATUS</subject><subject>TRANSPORTING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPB3yixW0DDSUTDRTclMzsjJL8ovyEjNSy3JqMzRVEjMzcxLVcioTCnKB8tlpqQqJOalKBQUpRYkFiWWZObnKeQC1eanKJRkpBal5qfxMLCmJeYUp_JCaW4GRTfXEGcP3dSC_PjU4oLEZJDh8c5-hobG5sam5oamjsbEqAEA1zs2Sw</recordid><startdate>20211203</startdate><enddate>20211203</enddate><creator>ZHENG GUANGBING</creator><creator>LI JIAN</creator><creator>HOU WEI</creator><creator>GOU GUOFENG</creator><creator>TIAN CHAO</creator><scope>EVB</scope></search><sort><creationdate>20211203</creationdate><title>Bis (2, 4-dichlorophenethyl) amine hydrochloride and preparation method thereof</title><author>ZHENG GUANGBING ; LI JIAN ; HOU WEI ; GOU GUOFENG ; TIAN CHAO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN113735715A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2021</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PERFORMING OPERATIONS</topic><topic>PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL</topic><topic>THEIR RELEVANT APPARATUS</topic><topic>TRANSPORTING</topic><toplevel>online_resources</toplevel><creatorcontrib>ZHENG GUANGBING</creatorcontrib><creatorcontrib>LI JIAN</creatorcontrib><creatorcontrib>HOU WEI</creatorcontrib><creatorcontrib>GOU GUOFENG</creatorcontrib><creatorcontrib>TIAN CHAO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ZHENG GUANGBING</au><au>LI JIAN</au><au>HOU WEI</au><au>GOU GUOFENG</au><au>TIAN CHAO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Bis (2, 4-dichlorophenethyl) amine hydrochloride and preparation method thereof</title><date>2021-12-03</date><risdate>2021</risdate><abstract>The invention belongs to the technical field of organic synthesis, and particularly relates to bis (2, 4-dichlorophenethyl) amine hydrochloride and a preparation method thereof. The structural formula of the bis (2, 4-dichlorophenethyl) amine hydrochloride is shown in the specification, and the 1H NMR spectrum parameters of the compound are as follows: 1H NMR (600MHz, (CD3) 2SO) delta 9.22 (s, 1H), 7.65 (s, 1H), 7.45 (d, 2H), 3.14-3.18 (t, 2H) and 3.09-3.13 (t, 2H). The preparation method comprises the following steps: adding 2, 4-dichlorophenylacetonitrile into an organic solvent, adding a catalyst, introducing hydrogen for reaction, and performing post-treatment to obtain the bis (2, 4-dichlorophenethyl) amine hydrochloride. The method has important significance on quality control of 2, 4-dichlorophenylethylamine, the steps are short, the raw materials are easy to obtain, and the product is high in yield and purity.
本发明属于有机合成技术领域，具体涉及一种双(2,4-二氯苯乙基)胺盐酸盐及其制备方法。所述的双(2,4-二氯苯乙基)胺盐酸盐，该化合物的结构式如下：该化合物的1H NMR图谱参数为：1</abstract><oa>free_for_read</oa></addata></record> |
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| title | Bis (2, 4-dichlorophenethyl) amine hydrochloride and preparation method thereof |
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