Ligustrazine-citric acid eutectic crystal as well as preparation method and application thereof
The invention relates to the technical field of eutectic crystals, in particular to a ligustrazine-citric acid eutectic crystal and a preparation method and application thereof. The ligustrazine-citric acid eutectic crystal has a crystal structure belonging to a monoclinic system and a P21/c space g...
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| creator | WANG TIANXIAO GAN RUIJING CHEN XIAN WANG ZHENYUAN ZHANG JIAHENG |
| description | The invention relates to the technical field of eutectic crystals, in particular to a ligustrazine-citric acid eutectic crystal and a preparation method and application thereof. The ligustrazine-citric acid eutectic crystal has a crystal structure belonging to a monoclinic system and a P21/c space group; unit cell parameters of the ligustrazine-citric acid eutectic crystal are that a is equal to 6.9962(7) angstroms, b is equal to 17.9367(17) angstroms, c is equal to 17.960(3) angstroms, alpha is equal to 90 degrees, beta is equal to 96.301 (11) degrees, gamma is equal to 90 degrees, and Z is equal to 4, and a unit cell volume V is equal to 2240.2(5) angstroms ; and the ligustrazine-citric acid eutectic crystal is composed of one molecule of citric acid and two molecules of ligustrazine, three carboxyl groups of the citric acid are introduced, one free carboxyl group can form two hydrogen bonds with one water molecule, and thus, the problem of poor water solubility of ligustrazine is solved.
本申请涉及共晶技术领域，具体而言，涉 |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS |
| title | Ligustrazine-citric acid eutectic crystal as well as preparation method and application thereof |
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