CYCLIC PEPTIDE ANTIBIOTICS

Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of lipoprotein signal peptidase II (LspA), a key protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided. 本文提供抗菌化合物，其中一些实施方案中的所述化合物具有广谱生物活性。在各种实施方案中，所述化合物通过抑制细菌中的关键蛋白质脂蛋白信号肽酶II(LspA)而起作用。还提供了使用本文所述的化合物的药物组合物和治疗方法。