Medical application of NRK in treatment and prognosis of lung cancer

The invention discloses medical application of NRK in treatment and prognosis of lung cancer. The invention specifically relates to application of the NRK in preparation of products for diagnosing prognosis of the lung cancer and application of the NRK in preparation of drugs for treating the lung c...

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Hauptverfasser:	SHEN XIAOJU, CHEN GANG, MO XIAOCHENG, SONG JINJING, LI LI, WEI TONGTONG, MO XIAOXIANG, HUANG ZHIGUANG, YANG JIE
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention discloses medical application of NRK in treatment and prognosis of lung cancer. The invention specifically relates to application of the NRK in preparation of products for diagnosing prognosis of the lung cancer and application of the NRK in preparation of drugs for treating the lung cancer. The invention also discloses application of a NRK neutralizing antibody in preparation of products for diagnosing lung cancer and application of the NRK neutralizing antibody in preparation of the drugs for treating the lung cancer. CAFs and NFs from LUAD I, II and III stages are analyzed by using RNA-seq and a comprehensive bioinformatics method, the specific expression of the NRK in lung cancer tumor-related fibroblasts is found, the NRK can be used as a clinical diagnosis biomarker of the lung cancer, and a better diagnosis and prognosis index can be provided; the NRK in the LUAD-related CAFs is obviously increased, and the NRK can be used as a target spot of LUAD combined treatment. 本发明公开了NRK在肺癌治疗和预后诊断中的