Marker for auxiliary diagnosis, prognosis diagnosis or risk stratification of acute myeloid leukemia and application thereof
The invention discloses a marker for auxiliary diagnosis, prognosis diagnosis or risk stratification of acute myeloid leukemia and application thereof. After multiple experiments, the patentee finds that compared with a normal person, the expression quantity of ARF3 in bone marrow of an acute myeloi...
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| creator | CHEN YING OUYANG GUIFANG ZOU DUOBING WU NINGNING ZHANG YI MU QITIAN |
| description | The invention discloses a marker for auxiliary diagnosis, prognosis diagnosis or risk stratification of acute myeloid leukemia and application thereof. After multiple experiments, the patentee finds that compared with a normal person, the expression quantity of ARF3 in bone marrow of an acute myeloid leukemia (hereinafter referred to as AML) patient is remarkably increased, which indicates that the ARF3 gene can be used as an auxiliary diagnosis marker of AML; meanwhile, the patentee also finds that the expression level of the ARF3 gene is significantly related to the prognosis of the AML patient, and the AML patient with high ARF3 expression has poorer overall survival and event-free survival, which prompts that the prognosis is poor, especially in a risk group in cytogenetics risk stratification; and therefore, the ARF3 gene can be used as a marker for prognostic diagnosis or risk stratification of AML.
本发明公开了一种急性髓系白血病的辅助诊断、预后诊断或危险度分层标记物及其应用。专利权人经多次实验后首次发现，与正常人相比，急性髓系白血病(以下简称AML)患者骨髓中ARF3表达量显著上调，表明ARF3基因能够作 |
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本发明公开了一种急性髓系白血病的辅助诊断、预后诊断或危险度分层标记物及其应用。专利权人经多次实验后首次发现，与正常人相比，急性髓系白血病(以下简称AML)患者骨髓中ARF3表达量显著上调，表明ARF3基因能够作</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; COMPOSITIONS THEREOF ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; CULTURE MEDIA ; ENZYMOLOGY ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20211112&DB=EPODOC&CC=CN&NR=113637750A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25555,76308</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20211112&DB=EPODOC&CC=CN&NR=113637750A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CHEN YING</creatorcontrib><creatorcontrib>OUYANG GUIFANG</creatorcontrib><creatorcontrib>ZOU DUOBING</creatorcontrib><creatorcontrib>WU NINGNING</creatorcontrib><creatorcontrib>ZHANG YI</creatorcontrib><creatorcontrib>MU QITIAN</creatorcontrib><title>Marker for auxiliary diagnosis, prognosis diagnosis or risk stratification of acute myeloid leukemia and application thereof</title><description>The invention discloses a marker for auxiliary diagnosis, prognosis diagnosis or risk stratification of acute myeloid leukemia and application thereof. After multiple experiments, the patentee finds that compared with a normal person, the expression quantity of ARF3 in bone marrow of an acute myeloid leukemia (hereinafter referred to as AML) patient is remarkably increased, which indicates that the ARF3 gene can be used as an auxiliary diagnosis marker of AML; meanwhile, the patentee also finds that the expression level of the ARF3 gene is significantly related to the prognosis of the AML patient, and the AML patient with high ARF3 expression has poorer overall survival and event-free survival, which prompts that the prognosis is poor, especially in a risk group in cytogenetics risk stratification; and therefore, the ARF3 gene can be used as a marker for prognostic diagnosis or risk stratification of AML.
本发明公开了一种急性髓系白血病的辅助诊断、预后诊断或危险度分层标记物及其应用。专利权人经多次实验后首次发现，与正常人相比，急性髓系白血病(以下简称AML)患者骨髓中ARF3表达量显著上调，表明ARF3基因能够作</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>COMPOSITIONS THEREOF</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyrEKwkAQBNA0FqL-w9orGIKmlqDYaGUflmRPl7vcHnsXMODHG1CxtZkZhjfNnmdUSwpGFLB_sGPUAVrGm5fIcQVB5T1_J4xWOVqISTGx4WZM8SAGsOkTQTeQE27BUW-pYwT0LWAI7ivTnZTEzLOJQRdp8elZtjwertVpTUFqigEb8pTq6pLnxa4oy-1mX_xjXn3oSLE</recordid><startdate>20211112</startdate><enddate>20211112</enddate><creator>CHEN YING</creator><creator>OUYANG GUIFANG</creator><creator>ZOU DUOBING</creator><creator>WU NINGNING</creator><creator>ZHANG YI</creator><creator>MU QITIAN</creator><scope>EVB</scope></search><sort><creationdate>20211112</creationdate><title>Marker for auxiliary diagnosis, prognosis diagnosis or risk stratification of acute myeloid leukemia and application thereof</title><author>CHEN YING ; OUYANG GUIFANG ; ZOU DUOBING ; WU NINGNING ; ZHANG YI ; MU QITIAN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN113637750A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2021</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>COMPOSITIONS THEREOF</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>CHEN YING</creatorcontrib><creatorcontrib>OUYANG GUIFANG</creatorcontrib><creatorcontrib>ZOU DUOBING</creatorcontrib><creatorcontrib>WU NINGNING</creatorcontrib><creatorcontrib>ZHANG YI</creatorcontrib><creatorcontrib>MU QITIAN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CHEN YING</au><au>OUYANG GUIFANG</au><au>ZOU DUOBING</au><au>WU NINGNING</au><au>ZHANG YI</au><au>MU QITIAN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Marker for auxiliary diagnosis, prognosis diagnosis or risk stratification of acute myeloid leukemia and application thereof</title><date>2021-11-12</date><risdate>2021</risdate><abstract>The invention discloses a marker for auxiliary diagnosis, prognosis diagnosis or risk stratification of acute myeloid leukemia and application thereof. After multiple experiments, the patentee finds that compared with a normal person, the expression quantity of ARF3 in bone marrow of an acute myeloid leukemia (hereinafter referred to as AML) patient is remarkably increased, which indicates that the ARF3 gene can be used as an auxiliary diagnosis marker of AML; meanwhile, the patentee also finds that the expression level of the ARF3 gene is significantly related to the prognosis of the AML patient, and the AML patient with high ARF3 expression has poorer overall survival and event-free survival, which prompts that the prognosis is poor, especially in a risk group in cytogenetics risk stratification; and therefore, the ARF3 gene can be used as a marker for prognostic diagnosis or risk stratification of AML.
本发明公开了一种急性髓系白血病的辅助诊断、预后诊断或危险度分层标记物及其应用。专利权人经多次实验后首次发现，与正常人相比，急性髓系白血病(以下简称AML)患者骨髓中ARF3表达量显著上调，表明ARF3基因能够作</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | Marker for auxiliary diagnosis, prognosis diagnosis or risk stratification of acute myeloid leukemia and application thereof |
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