Probiotics for reducing phosphorus and preparation method and application thereof
The invention discloses probiotics for reducing phosphorus, and belongs to the field of biomedical engineering. Probiotic escherichia coli Nissle 1917 is used as a host cell, and polyphosphate kinase ppk1 and recombinant plasmid Pet-28a (+) of the host are introduced. The invention further discloses...
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| creator | HE JINXUAN LIAO WENZHEN CHEN LAN ZHANG YIYAN GUAN TIANJUN TIAN YUCHEN MOU ZHIXIANG |
| description | The invention discloses probiotics for reducing phosphorus, and belongs to the field of biomedical engineering. Probiotic escherichia coli Nissle 1917 is used as a host cell, and polyphosphate kinase ppk1 and recombinant plasmid Pet-28a (+) of the host are introduced. The invention further discloses application of the probiotics. The probiotics disclosed by the invention have the effect of excessively absorbing phosphorus and can be used for reducing phosphorus in vivo; and compared with an existing phosphorus reducing method, a method adopting the probiotics have the advantages that the content of blood calcium cannot be additionally increased, hypercalcemia and blood calcium calcification cannot be caused, heavy metal intake is avoided, and heavy metal accumulation in vivo cannot be caused.
本发明公开了一种用于降磷的益生菌，属于生物医学工程领域，是以益生菌大肠杆菌Nissle 1917为宿主细胞，并导入宿主自身的多聚磷酸盐激酶ppk1和重组质粒Pet-28a(+)；还公开了所述益生菌的用途；本发明的益生菌具有超量吸收磷的作用，可用于体内降磷作用，相对于现有的降磷方法，不会额外增加血钙含量，不会引起高钙血症和血钙钙化，也没有重金属摄入，不会造成体内重金属累积。 |
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本发明公开了一种用于降磷的益生菌，属于生物医学工程领域，是以益生菌大肠杆菌Nissle 1917为宿主细胞，并导入宿主自身的多聚磷酸盐激酶ppk1和重组质粒Pet-28a(+)；还公开了所述益生菌的用途；本发明的益生菌具有超量吸收磷的作用，可用于体内降磷作用，相对于现有的降磷方法，不会额外增加血钙含量，不会引起高钙血症和血钙钙化，也没有重金属摄入，不会造成体内重金属累积。</description><language>chi ; eng</language><subject>ADDITIVE MANUFACTURING TECHNOLOGY ; ADDITIVE MANUFACTURING, i.e. MANUFACTURING OFTHREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVEAGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING,STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING ; BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PERFORMING OPERATIONS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROCESSES USING MICROORGANISMS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; TRANSPORTING ; VINEGAR ; WINE</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20211029&DB=EPODOC&CC=CN&NR=113564091A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20211029&DB=EPODOC&CC=CN&NR=113564091A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HE JINXUAN</creatorcontrib><creatorcontrib>LIAO WENZHEN</creatorcontrib><creatorcontrib>CHEN LAN</creatorcontrib><creatorcontrib>ZHANG YIYAN</creatorcontrib><creatorcontrib>GUAN TIANJUN</creatorcontrib><creatorcontrib>TIAN YUCHEN</creatorcontrib><creatorcontrib>MOU ZHIXIANG</creatorcontrib><title>Probiotics for reducing phosphorus and preparation method and application thereof</title><description>The invention discloses probiotics for reducing phosphorus, and belongs to the field of biomedical engineering. Probiotic escherichia coli Nissle 1917 is used as a host cell, and polyphosphate kinase ppk1 and recombinant plasmid Pet-28a (+) of the host are introduced. The invention further discloses application of the probiotics. The probiotics disclosed by the invention have the effect of excessively absorbing phosphorus and can be used for reducing phosphorus in vivo; and compared with an existing phosphorus reducing method, a method adopting the probiotics have the advantages that the content of blood calcium cannot be additionally increased, hypercalcemia and blood calcium calcification cannot be caused, heavy metal intake is avoided, and heavy metal accumulation in vivo cannot be caused.
本发明公开了一种用于降磷的益生菌，属于生物医学工程领域，是以益生菌大肠杆菌Nissle 1917为宿主细胞，并导入宿主自身的多聚磷酸盐激酶ppk1和重组质粒Pet-28a(+)；还公开了所述益生菌的用途；本发明的益生菌具有超量吸收磷的作用，可用于体内降磷作用，相对于现有的降磷方法，不会额外增加血钙含量，不会引起高钙血症和血钙钙化，也没有重金属摄入，不会造成体内重金属累积。</description><subject>ADDITIVE MANUFACTURING TECHNOLOGY</subject><subject>ADDITIVE MANUFACTURING, i.e. MANUFACTURING OFTHREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVEAGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING,STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING</subject><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PERFORMING OPERATIONS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROCESSES USING MICROORGANISMS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>TRANSPORTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNikEKwjAQAHPxIOof1gcIhqrgUYriSRS8lzXZNIGaXTbp_xX1AR6GgWGm5nZVfiSuyRUIrKDkR5dyDxK5vNGxAGYPoiSoWBNneFKN7D8ZRYbkvrlGUuIwN5OAQ6HFzzOzPB3v7XlFwh0VQUeZatderG22u816bw_NP88LPrw4cg</recordid><startdate>20211029</startdate><enddate>20211029</enddate><creator>HE JINXUAN</creator><creator>LIAO WENZHEN</creator><creator>CHEN LAN</creator><creator>ZHANG YIYAN</creator><creator>GUAN TIANJUN</creator><creator>TIAN YUCHEN</creator><creator>MOU ZHIXIANG</creator><scope>EVB</scope></search><sort><creationdate>20211029</creationdate><title>Probiotics for reducing phosphorus and preparation method and application thereof</title><author>HE JINXUAN ; LIAO WENZHEN ; CHEN LAN ; ZHANG YIYAN ; GUAN TIANJUN ; TIAN YUCHEN ; MOU ZHIXIANG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN113564091A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2021</creationdate><topic>ADDITIVE MANUFACTURING TECHNOLOGY</topic><topic>ADDITIVE MANUFACTURING, i.e. MANUFACTURING OFTHREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVEAGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING,STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING</topic><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PERFORMING OPERATIONS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROCESSES USING MICROORGANISMS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>TRANSPORTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>HE JINXUAN</creatorcontrib><creatorcontrib>LIAO WENZHEN</creatorcontrib><creatorcontrib>CHEN LAN</creatorcontrib><creatorcontrib>ZHANG YIYAN</creatorcontrib><creatorcontrib>GUAN TIANJUN</creatorcontrib><creatorcontrib>TIAN YUCHEN</creatorcontrib><creatorcontrib>MOU ZHIXIANG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HE JINXUAN</au><au>LIAO WENZHEN</au><au>CHEN LAN</au><au>ZHANG YIYAN</au><au>GUAN TIANJUN</au><au>TIAN YUCHEN</au><au>MOU ZHIXIANG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Probiotics for reducing phosphorus and preparation method and application thereof</title><date>2021-10-29</date><risdate>2021</risdate><abstract>The invention discloses probiotics for reducing phosphorus, and belongs to the field of biomedical engineering. Probiotic escherichia coli Nissle 1917 is used as a host cell, and polyphosphate kinase ppk1 and recombinant plasmid Pet-28a (+) of the host are introduced. The invention further discloses application of the probiotics. The probiotics disclosed by the invention have the effect of excessively absorbing phosphorus and can be used for reducing phosphorus in vivo; and compared with an existing phosphorus reducing method, a method adopting the probiotics have the advantages that the content of blood calcium cannot be additionally increased, hypercalcemia and blood calcium calcification cannot be caused, heavy metal intake is avoided, and heavy metal accumulation in vivo cannot be caused.
本发明公开了一种用于降磷的益生菌，属于生物医学工程领域，是以益生菌大肠杆菌Nissle 1917为宿主细胞，并导入宿主自身的多聚磷酸盐激酶ppk1和重组质粒Pet-28a(+)；还公开了所述益生菌的用途；本发明的益生菌具有超量吸收磷的作用，可用于体内降磷作用，相对于现有的降磷方法，不会额外增加血钙含量，不会引起高钙血症和血钙钙化，也没有重金属摄入，不会造成体内重金属累积。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ADDITIVE MANUFACTURING TECHNOLOGY ADDITIVE MANUFACTURING, i.e. MANUFACTURING OFTHREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVEAGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING,STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PERFORMING OPERATIONS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TRANSPORTING VINEGAR WINE |
| title | Probiotics for reducing phosphorus and preparation method and application thereof |
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