Polymer carrier with pH and redox dual response, drug-loaded micelle, preparation method and application
The invention discloses a polymer carrier with pH and redox dual response, a drug-loaded micelle and a preparation method and application. The polymer carrier comprises a hydrophilic shell and a hydrophobic core, the hydrophilic shell is a polyethylene glycol block, and the hydrophobic core is a blo...
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| creator | LAN YANG TANG ZHILI WANG YALI SUI HEHUAN LIANG JING ZHANG SHIJIN SU QIANG CHEN LIJUAN |
| description | The invention discloses a polymer carrier with pH and redox dual response, a drug-loaded micelle and a preparation method and application. The polymer carrier comprises a hydrophilic shell and a hydrophobic core, the hydrophilic shell is a polyethylene glycol block, and the hydrophobic core is a block formed by connecting poly(2-(diisopropylamino)ethyl methacrylate) and poly(L-lysine). The polymer carrier can load drugs to form drug-loaded micelles, the drug-loaded micelles can keep good integrity in blood circulation and target to tumor cells, after the drug-loaded micelles enter the tumor cells, under the action of high-concentration GSH and low pH, disulfide bonds are broken, PDPA nuclei are opened, the drugs are released into cell nuclei, and under the weak acid condition, the positive charges on the surface of the drug-loaded micelle are increased, so that the drug intake of cell nucleuses can be improved, the drug delivery effect in the tumor treatment process is further remarkably improved, and meanwhi |
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The polymer carrier comprises a hydrophilic shell and a hydrophobic core, the hydrophilic shell is a polyethylene glycol block, and the hydrophobic core is a block formed by connecting poly(2-(diisopropylamino)ethyl methacrylate) and poly(L-lysine). The polymer carrier can load drugs to form drug-loaded micelles, the drug-loaded micelles can keep good integrity in blood circulation and target to tumor cells, after the drug-loaded micelles enter the tumor cells, under the action of high-concentration GSH and low pH, disulfide bonds are broken, PDPA nuclei are opened, the drugs are released into cell nuclei, and under the weak acid condition, the positive charges on the surface of the drug-loaded micelle are increased, so that the drug intake of cell nucleuses can be improved, the drug delivery effect in the tumor treatment process is further remarkably improved, and meanwhi</description><language>chi ; eng</language><subject>CHEMISTRY ; COMPOSITIONS BASED THEREON ; HUMAN NECESSITIES ; HYGIENE ; MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS ; MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC MACROMOLECULAR COMPOUNDS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; THEIR PREPARATION OR CHEMICAL WORKING-UP</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20211026&DB=EPODOC&CC=CN&NR=113549184A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76294</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20211026&DB=EPODOC&CC=CN&NR=113549184A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LAN YANG</creatorcontrib><creatorcontrib>TANG ZHILI</creatorcontrib><creatorcontrib>WANG YALI</creatorcontrib><creatorcontrib>SUI HEHUAN</creatorcontrib><creatorcontrib>LIANG JING</creatorcontrib><creatorcontrib>ZHANG SHIJIN</creatorcontrib><creatorcontrib>SU QIANG</creatorcontrib><creatorcontrib>CHEN LIJUAN</creatorcontrib><title>Polymer carrier with pH and redox dual response, drug-loaded micelle, preparation method and application</title><description>The invention discloses a polymer carrier with pH and redox dual response, a drug-loaded micelle and a preparation method and application. The polymer carrier comprises a hydrophilic shell and a hydrophobic core, the hydrophilic shell is a polyethylene glycol block, and the hydrophobic core is a block formed by connecting poly(2-(diisopropylamino)ethyl methacrylate) and poly(L-lysine). The polymer carrier can load drugs to form drug-loaded micelles, the drug-loaded micelles can keep good integrity in blood circulation and target to tumor cells, after the drug-loaded micelles enter the tumor cells, under the action of high-concentration GSH and low pH, disulfide bonds are broken, PDPA nuclei are opened, the drugs are released into cell nuclei, and under the weak acid condition, the positive charges on the surface of the drug-loaded micelle are increased, so that the drug intake of cell nucleuses can be improved, the drug delivery effect in the tumor treatment process is further remarkably improved, and meanwhi</description><subject>CHEMISTRY</subject><subject>COMPOSITIONS BASED THEREON</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS</subject><subject>MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC MACROMOLECULAR COMPOUNDS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>THEIR PREPARATION OR CHEMICAL WORKING-UP</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjDEKwkAQRdNYiHqHsTdFSAQtJSipxMI-DDujWdjsDLsb1Nu7BA9g9T6Pz1sWw03cZ-QABkOwmS-bBtAO0BMEJnkDTejyjCo-8g4oTM_SCRITjNawc1lqYMWAyYqHkdMgNAdQ1Vkz63WxeKCLvPlxVWwv53vblazS5zga9pz69lpV9b45VofmVP_z-QLI8EAN</recordid><startdate>20211026</startdate><enddate>20211026</enddate><creator>LAN YANG</creator><creator>TANG ZHILI</creator><creator>WANG YALI</creator><creator>SUI HEHUAN</creator><creator>LIANG JING</creator><creator>ZHANG SHIJIN</creator><creator>SU QIANG</creator><creator>CHEN LIJUAN</creator><scope>EVB</scope></search><sort><creationdate>20211026</creationdate><title>Polymer carrier with pH and redox dual response, drug-loaded micelle, preparation method and application</title><author>LAN YANG ; TANG ZHILI ; WANG YALI ; SUI HEHUAN ; LIANG JING ; ZHANG SHIJIN ; SU QIANG ; CHEN LIJUAN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN113549184A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2021</creationdate><topic>CHEMISTRY</topic><topic>COMPOSITIONS BASED THEREON</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS</topic><topic>MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC MACROMOLECULAR COMPOUNDS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>THEIR PREPARATION OR CHEMICAL WORKING-UP</topic><toplevel>online_resources</toplevel><creatorcontrib>LAN YANG</creatorcontrib><creatorcontrib>TANG ZHILI</creatorcontrib><creatorcontrib>WANG YALI</creatorcontrib><creatorcontrib>SUI HEHUAN</creatorcontrib><creatorcontrib>LIANG JING</creatorcontrib><creatorcontrib>ZHANG SHIJIN</creatorcontrib><creatorcontrib>SU QIANG</creatorcontrib><creatorcontrib>CHEN LIJUAN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LAN YANG</au><au>TANG ZHILI</au><au>WANG YALI</au><au>SUI HEHUAN</au><au>LIANG JING</au><au>ZHANG SHIJIN</au><au>SU QIANG</au><au>CHEN LIJUAN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Polymer carrier with pH and redox dual response, drug-loaded micelle, preparation method and application</title><date>2021-10-26</date><risdate>2021</risdate><abstract>The invention discloses a polymer carrier with pH and redox dual response, a drug-loaded micelle and a preparation method and application. The polymer carrier comprises a hydrophilic shell and a hydrophobic core, the hydrophilic shell is a polyethylene glycol block, and the hydrophobic core is a block formed by connecting poly(2-(diisopropylamino)ethyl methacrylate) and poly(L-lysine). The polymer carrier can load drugs to form drug-loaded micelles, the drug-loaded micelles can keep good integrity in blood circulation and target to tumor cells, after the drug-loaded micelles enter the tumor cells, under the action of high-concentration GSH and low pH, disulfide bonds are broken, PDPA nuclei are opened, the drugs are released into cell nuclei, and under the weak acid condition, the positive charges on the surface of the drug-loaded micelle are increased, so that the drug intake of cell nucleuses can be improved, the drug delivery effect in the tumor treatment process is further remarkably improved, and meanwhi</abstract><oa>free_for_read</oa></addata></record> |
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| language | chi ; eng |
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| subjects | CHEMISTRY COMPOSITIONS BASED THEREON HUMAN NECESSITIES HYGIENE MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR PREPARATION OR CHEMICAL WORKING-UP |
| title | Polymer carrier with pH and redox dual response, drug-loaded micelle, preparation method and application |
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