Method for synthesizing indolo-polysubstituted cyclopentane compound based on alkyl-substituted allyl alcohol silyl ether

The invention provides a method for synthesizing an indolo-polysubstituted cyclopentane compound based on alkyl-substituted allyl alcohol silyl ether, which relates to the technical field of organic synthesis. The synthesis method provided by the invention comprises the following steps of by taking alkyl-substituted allyl alcohol silyl ether and beta, gamma-unsaturated keto ester as reaction raw materials, catalyzing in an organic solvent through a Lewis acid catalyst to obtain the indole-polysubstituted cyclopentane compound. The synthesis method provided by the invention has the characteristics of simple reaction process operation, cheap and easily available raw materials, wide application range of functional groups and high product yield. 本发明提供了一种基于烷基取代的烯丙醇硅醚合成吲哚并多取代环戊烷类化合物的方法，涉及有机合成技术领域。本发明提供的合成方法包括以下步骤：以烷基取代的烯丙醇硅醚、β,γ-不饱和酮酸酯为反应原料，在有机溶剂下经路易斯酸催化剂催化得到所述吲哚并多取代环戊烷类化合物。本发明的合成方法具有反应过程操作简单、原料廉价易得、官能团适用范围广，并且产物收率高的特点。