Nano antibody recombinant protein for treating rheumatoid arthritis

The invention discloses a nano antibody recombinant protein for treating rheumatoid arthritis, and belongs to the field of genetic engineering. The nano antibody recombinant protein is a fusion antibody formed by fusing sequences of nano antibodies of camel source anti-TNF-alpha and anti-human serum protein through flexible connecting peptide. The amino acid sequence is shown as SEQ ID No.1 or comprises an amino acid sequence which has at least 80%, 85%, 90%, 95%, 98% or 99% identity with the SEQ ID No.1 and has the same function. The anti-TNF-alpha nano antibody recombinant protein provided by the invention can be used for preventing or treating rheumatoid arthritis, and has the advantages of safety, reliability and strong specificity. 本发明公开了一种用于治疗类风湿性关节炎的纳米抗体重组蛋白，属于基因工程领域，该纳米抗体重组蛋白为将骆驼源抗TNF-α与抗人血清蛋白的纳米抗体的序列通过柔性连接肽融合在一起，形成融合抗体，其氨基酸序列如SEQ ID No.1所示或包括与SEQ ID No.1具有至少80％、85％、90％、95％、98％或99％同一性的且具有相同功能的氨基酸序列；本发明提供一种抗TNF-α纳米抗体重组蛋白，可用于类风湿性关节炎的预防或治疗，具有安全可靠、特异性强的优势。