Inhibitor of collagen-stimulated platelet aggregation
本发明涉及与LH-RH受体有极好亲和力的LH-RH肽类似物，其分子式为：A1-A2-A3-A4-A5-A6-HAA-A7-Pro-Z，其中Z、A1到A7如本说明书中所定义，HAA为含有7-20个碳原子的非芳香族疏水氨基酸。本发明还涉及所述肽类似物的用途和包含所述肽类似物的药物组合物。 PCT No. PCT/EP94/02087 Sec. 371 Date Feb. 28, 1995 Sec. 102(e) Date Feb. 28, 1995 PCT Filed Jun. 28, 1994 PCT Pub. No. WO95/01375 PCT Pub. Date Jan. 12, 1995...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Patent |
| Sprache: | chi ; eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | JUERGEN HEMBERGER GUIDO MELZER |
| description | 本发明涉及与LH-RH受体有极好亲和力的LH-RH肽类似物，其分子式为：A1-A2-A3-A4-A5-A6-HAA-A7-Pro-Z，其中Z、A1到A7如本说明书中所定义，HAA为含有7-20个碳原子的非芳香族疏水氨基酸。本发明还涉及所述肽类似物的用途和包含所述肽类似物的药物组合物。
PCT No. PCT/EP94/02087 Sec. 371 Date Feb. 28, 1995 Sec. 102(e) Date Feb. 28, 1995 PCT Filed Jun. 28, 1994 PCT Pub. No. WO95/01375 PCT Pub. Date Jan. 12, 1995A protein isolated from crude extracts of Hirudo medicinalis is disclosed, which strongly inhibits the binding to collagen of platelets and their subsequent activation, which leads to platelet aggregation and thrombus formation. Additionally the protein prevents binding of von Willebrand factor to collagen. Described is a method for isolation and purification of the protein as well as its use for blocking collagen-stimulated platelet aggregation. The new protein (Brandinin) has a molweight of approximately 15 kD, binds to collagen but has no collagen-cleaving activity. The protein is useful in the prophylaxis, prevention and treatment of thrombotic diseaeses and for coating of blood-contacting materials, rendering them thromboresistant. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN1134451CC</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN1134451CC</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN1134451CC3</originalsourceid><addsrcrecordid>eNrjZDD1zMvITMosyS9SyE9TSM7PyUlMT83TLS7JzC3NSSxJTVEoAFE5qSUKienpRanpiSWZ-Xk8DKxpiTnFqbxQmptBwc01xNlDN7UgPz61uCAxOTUvtSTe2c_Q0NjExNTQ2dmYCCUARRQtWA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Inhibitor of collagen-stimulated platelet aggregation</title><source>esp@cenet</source><creator>JUERGEN HEMBERGER ; GUIDO MELZER</creator><creatorcontrib>JUERGEN HEMBERGER ; GUIDO MELZER</creatorcontrib><description>本发明涉及与LH-RH受体有极好亲和力的LH-RH肽类似物，其分子式为：A1-A2-A3-A4-A5-A6-HAA-A7-Pro-Z，其中Z、A1到A7如本说明书中所定义，HAA为含有7-20个碳原子的非芳香族疏水氨基酸。本发明还涉及所述肽类似物的用途和包含所述肽类似物的药物组合物。
PCT No. PCT/EP94/02087 Sec. 371 Date Feb. 28, 1995 Sec. 102(e) Date Feb. 28, 1995 PCT Filed Jun. 28, 1994 PCT Pub. No. WO95/01375 PCT Pub. Date Jan. 12, 1995A protein isolated from crude extracts of Hirudo medicinalis is disclosed, which strongly inhibits the binding to collagen of platelets and their subsequent activation, which leads to platelet aggregation and thrombus formation. Additionally the protein prevents binding of von Willebrand factor to collagen. Described is a method for isolation and purification of the protein as well as its use for blocking collagen-stimulated platelet aggregation. The new protein (Brandinin) has a molweight of approximately 15 kD, binds to collagen but has no collagen-cleaving activity. The protein is useful in the prophylaxis, prevention and treatment of thrombotic diseaeses and for coating of blood-contacting materials, rendering them thromboresistant.</description><edition>7</edition><language>chi ; eng</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2004</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040114&DB=EPODOC&CC=CN&NR=1134451C$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040114&DB=EPODOC&CC=CN&NR=1134451C$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>JUERGEN HEMBERGER</creatorcontrib><creatorcontrib>GUIDO MELZER</creatorcontrib><title>Inhibitor of collagen-stimulated platelet aggregation</title><description>本发明涉及与LH-RH受体有极好亲和力的LH-RH肽类似物，其分子式为：A1-A2-A3-A4-A5-A6-HAA-A7-Pro-Z，其中Z、A1到A7如本说明书中所定义，HAA为含有7-20个碳原子的非芳香族疏水氨基酸。本发明还涉及所述肽类似物的用途和包含所述肽类似物的药物组合物。
PCT No. PCT/EP94/02087 Sec. 371 Date Feb. 28, 1995 Sec. 102(e) Date Feb. 28, 1995 PCT Filed Jun. 28, 1994 PCT Pub. No. WO95/01375 PCT Pub. Date Jan. 12, 1995A protein isolated from crude extracts of Hirudo medicinalis is disclosed, which strongly inhibits the binding to collagen of platelets and their subsequent activation, which leads to platelet aggregation and thrombus formation. Additionally the protein prevents binding of von Willebrand factor to collagen. Described is a method for isolation and purification of the protein as well as its use for blocking collagen-stimulated platelet aggregation. The new protein (Brandinin) has a molweight of approximately 15 kD, binds to collagen but has no collagen-cleaving activity. The protein is useful in the prophylaxis, prevention and treatment of thrombotic diseaeses and for coating of blood-contacting materials, rendering them thromboresistant.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2004</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDD1zMvITMosyS9SyE9TSM7PyUlMT83TLS7JzC3NSSxJTVEoAFE5qSUKienpRanpiSWZ-Xk8DKxpiTnFqbxQmptBwc01xNlDN7UgPz61uCAxOTUvtSTe2c_Q0NjExNTQ2dmYCCUARRQtWA</recordid><startdate>20040114</startdate><enddate>20040114</enddate><creator>JUERGEN HEMBERGER</creator><creator>GUIDO MELZER</creator><scope>EVB</scope></search><sort><creationdate>20040114</creationdate><title>Inhibitor of collagen-stimulated platelet aggregation</title><author>JUERGEN HEMBERGER ; GUIDO MELZER</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN1134451CC3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2004</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>JUERGEN HEMBERGER</creatorcontrib><creatorcontrib>GUIDO MELZER</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>JUERGEN HEMBERGER</au><au>GUIDO MELZER</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Inhibitor of collagen-stimulated platelet aggregation</title><date>2004-01-14</date><risdate>2004</risdate><abstract>本发明涉及与LH-RH受体有极好亲和力的LH-RH肽类似物，其分子式为：A1-A2-A3-A4-A5-A6-HAA-A7-Pro-Z，其中Z、A1到A7如本说明书中所定义，HAA为含有7-20个碳原子的非芳香族疏水氨基酸。本发明还涉及所述肽类似物的用途和包含所述肽类似物的药物组合物。
PCT No. PCT/EP94/02087 Sec. 371 Date Feb. 28, 1995 Sec. 102(e) Date Feb. 28, 1995 PCT Filed Jun. 28, 1994 PCT Pub. No. WO95/01375 PCT Pub. Date Jan. 12, 1995A protein isolated from crude extracts of Hirudo medicinalis is disclosed, which strongly inhibits the binding to collagen of platelets and their subsequent activation, which leads to platelet aggregation and thrombus formation. Additionally the protein prevents binding of von Willebrand factor to collagen. Described is a method for isolation and purification of the protein as well as its use for blocking collagen-stimulated platelet aggregation. The new protein (Brandinin) has a molweight of approximately 15 kD, binds to collagen but has no collagen-cleaving activity. The protein is useful in the prophylaxis, prevention and treatment of thrombotic diseaeses and for coating of blood-contacting materials, rendering them thromboresistant.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | chi ; eng |
| recordid | cdi_epo_espacenet_CN1134451CC |
| source | esp@cenet |
| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Inhibitor of collagen-stimulated platelet aggregation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T01%3A26%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=JUERGEN%20HEMBERGER&rft.date=2004-01-14&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN1134451CC%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |