Novel application of triterpenoid acid compound as A beta fiber formation inhibitor drug
The invention relates to novel application of a triterpenoid acid compound as an A beta fiber formation inhibitor drug, and particularly relates to application of the triterpenoid acid compound in the A beta fiber formation inhibitor drug. The triterpenoid acid compound is at least one of polyporus...
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| creator | QIU WENQIAO GUO MINSONG ZHOU XIAOGANG TANG YONG WU JIANMING ZHU FENGDAN WU ANGUO QIN DALIAN |
| description | The invention relates to novel application of a triterpenoid acid compound as an A beta fiber formation inhibitor drug, and particularly relates to application of the triterpenoid acid compound in the A beta fiber formation inhibitor drug. The triterpenoid acid compound is at least one of polyporus umbellatus acid C, dehydro-geosolic acid and geosolic acid. Multiple aspects verify that the triterpenoid acid compound can remarkably inhibit formation of A beta fibers, save PC-12 cells induced by A beta (1-42), reduce the A beta content of caenorhabditis elegans AD and improve the behavior ability of caenorhabditis elegans AD. Molecular docking results show that the triterpenoid acid compound has good binding performance with A beta. The compound capable of inhibiting formation of the A beta fibers is researched, and the compound has very important social significance in developing drugs for neuroprotection.
本发明涉及了一种三萜酸类化合物作为Aβ纤维形成抑制剂药物的新用途，具体涉及一种三萜酸类化合物在Aβ纤维形成抑制剂药物中的用途；所述三萜酸类化合物为猪苓酸C、去氢土莫酸和土莫酸中的至少一种。经过多方验证，本发明提 |
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本发明涉及了一种三萜酸类化合物作为Aβ纤维形成抑制剂药物的新用途，具体涉及一种三萜酸类化合物在Aβ纤维形成抑制剂药物中的用途；所述三萜酸类化合物为猪苓酸C、去氢土莫酸和土莫酸中的至少一种。经过多方验证，本发明提</description><language>chi ; eng</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210907&DB=EPODOC&CC=CN&NR=113350360A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210907&DB=EPODOC&CC=CN&NR=113350360A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>QIU WENQIAO</creatorcontrib><creatorcontrib>GUO MINSONG</creatorcontrib><creatorcontrib>ZHOU XIAOGANG</creatorcontrib><creatorcontrib>TANG YONG</creatorcontrib><creatorcontrib>WU JIANMING</creatorcontrib><creatorcontrib>ZHU FENGDAN</creatorcontrib><creatorcontrib>WU ANGUO</creatorcontrib><creatorcontrib>QIN DALIAN</creatorcontrib><title>Novel application of triterpenoid acid compound as A beta fiber formation inhibitor drug</title><description>The invention relates to novel application of a triterpenoid acid compound as an A beta fiber formation inhibitor drug, and particularly relates to application of the triterpenoid acid compound in the A beta fiber formation inhibitor drug. The triterpenoid acid compound is at least one of polyporus umbellatus acid C, dehydro-geosolic acid and geosolic acid. Multiple aspects verify that the triterpenoid acid compound can remarkably inhibit formation of A beta fibers, save PC-12 cells induced by A beta (1-42), reduce the A beta content of caenorhabditis elegans AD and improve the behavior ability of caenorhabditis elegans AD. Molecular docking results show that the triterpenoid acid compound has good binding performance with A beta. The compound capable of inhibiting formation of the A beta fibers is researched, and the compound has very important social significance in developing drugs for neuroprotection.
本发明涉及了一种三萜酸类化合物作为Aβ纤维形成抑制剂药物的新用途，具体涉及一种三萜酸类化合物在Aβ纤维形成抑制剂药物中的用途；所述三萜酸类化合物为猪苓酸C、去氢土莫酸和土莫酸中的至少一种。经过多方验证，本发明提</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNi0EKwjAQRbtxIeodxgMILUH3pVRcdeXCXUnSiQ6kmTCZen4LegA3__Hg_W31GPiNEWzOkbxV4gQcQIUUJWNimsD6dTzPmZe0WoEWHKqFQA4FAsv8_VF6kSNlgUmW577aBBsLHn7cVcdrf-9uJ8w8YsnWY0Idu6FpjDnX5lK35p_mA5qfOik</recordid><startdate>20210907</startdate><enddate>20210907</enddate><creator>QIU WENQIAO</creator><creator>GUO MINSONG</creator><creator>ZHOU XIAOGANG</creator><creator>TANG YONG</creator><creator>WU JIANMING</creator><creator>ZHU FENGDAN</creator><creator>WU ANGUO</creator><creator>QIN DALIAN</creator><scope>EVB</scope></search><sort><creationdate>20210907</creationdate><title>Novel application of triterpenoid acid compound as A beta fiber formation inhibitor drug</title><author>QIU WENQIAO ; GUO MINSONG ; ZHOU XIAOGANG ; TANG YONG ; WU JIANMING ; ZHU FENGDAN ; WU ANGUO ; QIN DALIAN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN113350360A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2021</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>QIU WENQIAO</creatorcontrib><creatorcontrib>GUO MINSONG</creatorcontrib><creatorcontrib>ZHOU XIAOGANG</creatorcontrib><creatorcontrib>TANG YONG</creatorcontrib><creatorcontrib>WU JIANMING</creatorcontrib><creatorcontrib>ZHU FENGDAN</creatorcontrib><creatorcontrib>WU ANGUO</creatorcontrib><creatorcontrib>QIN DALIAN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>QIU WENQIAO</au><au>GUO MINSONG</au><au>ZHOU XIAOGANG</au><au>TANG YONG</au><au>WU JIANMING</au><au>ZHU FENGDAN</au><au>WU ANGUO</au><au>QIN DALIAN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Novel application of triterpenoid acid compound as A beta fiber formation inhibitor drug</title><date>2021-09-07</date><risdate>2021</risdate><abstract>The invention relates to novel application of a triterpenoid acid compound as an A beta fiber formation inhibitor drug, and particularly relates to application of the triterpenoid acid compound in the A beta fiber formation inhibitor drug. The triterpenoid acid compound is at least one of polyporus umbellatus acid C, dehydro-geosolic acid and geosolic acid. Multiple aspects verify that the triterpenoid acid compound can remarkably inhibit formation of A beta fibers, save PC-12 cells induced by A beta (1-42), reduce the A beta content of caenorhabditis elegans AD and improve the behavior ability of caenorhabditis elegans AD. Molecular docking results show that the triterpenoid acid compound has good binding performance with A beta. The compound capable of inhibiting formation of the A beta fibers is researched, and the compound has very important social significance in developing drugs for neuroprotection.
本发明涉及了一种三萜酸类化合物作为Aβ纤维形成抑制剂药物的新用途，具体涉及一种三萜酸类化合物在Aβ纤维形成抑制剂药物中的用途；所述三萜酸类化合物为猪苓酸C、去氢土莫酸和土莫酸中的至少一种。经过多方验证，本发明提</abstract><oa>free_for_read</oa></addata></record> |
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| title | Novel application of triterpenoid acid compound as A beta fiber formation inhibitor drug |
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