NUPR1 INHIBITION FOR TREATING CANCER

NUPR1 INHIBITION FOR TREATING CANCER

The present invention relates to the treatment of a tumor selected from the group consisting of pancreatic cancer, liver cancer, melanoma, colon cancer, glioblastoma, osteosarcoma, prostate cancer and breast cancer, more particularly pancreatic cancer. The inventors found a novel family compounds of...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: XIA YI, SANTOFIMIA PATRICIA, VELAZQUEZ CAMPOY ADRIAN, PENG LING, ABIAN FRANCO OLGA, IOVANNA JUAN, NEIRA JOSE LUIS, RIZZUTI BRUNO
Format: Patent
Sprache:chi ; eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator XIA YI
SANTOFIMIA PATRICIA
VELAZQUEZ CAMPOY ADRIAN
PENG LING
ABIAN FRANCO OLGA
IOVANNA JUAN
NEIRA JOSE LUIS
RIZZUTI BRUNO
description The present invention relates to the treatment of a tumor selected from the group consisting of pancreatic cancer, liver cancer, melanoma, colon cancer, glioblastoma, osteosarcoma, prostate cancer and breast cancer, more particularly pancreatic cancer. The inventors found a novel family compounds of formula (I) able to treat a variety of cancers by inhibiting NUPR1, a stress-inducible 82-amino-acid-long, intrinsically disordered member of the AT-hook family of chromatin proteins. Thus, the present invention relates to a compound of formula (I) for its use in the treatment of a tumor selected from the group consisting of pancreatic cancer, liver cancer, melanoma, colon cancer, glioblastoma, osteosarcoma, prostate cancer and breast cancer. In particular, the inventors tested compounds of formula (I) on four well characterized primary pancreatic cancer-derived cells 02.063 and LIPC (Basal subtype), Foic8b (derived from a liver metastasis) and HN14 (Classical subtype), as well as on other cellular lines derived f
format Patent
fullrecord <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN113164492A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN113164492A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN113164492A3</originalsourceid><addsrcrecordid>eNrjZFDxCw0IMlTw9PPwdPIM8fT3U3DzD1IICXJ1DPH0c1dwdvRzdg3iYWBNS8wpTuWF0twMim6uIc4euqkF-fGpxQWJyal5qSXxzn6GhsaGZiYmlkaOxsSoAQBxPyLd</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>NUPR1 INHIBITION FOR TREATING CANCER</title><source>esp@cenet</source><creator>XIA YI ; SANTOFIMIA PATRICIA ; VELAZQUEZ CAMPOY ADRIAN ; PENG LING ; ABIAN FRANCO OLGA ; IOVANNA JUAN ; NEIRA JOSE LUIS ; RIZZUTI BRUNO</creator><creatorcontrib>XIA YI ; SANTOFIMIA PATRICIA ; VELAZQUEZ CAMPOY ADRIAN ; PENG LING ; ABIAN FRANCO OLGA ; IOVANNA JUAN ; NEIRA JOSE LUIS ; RIZZUTI BRUNO</creatorcontrib><description>The present invention relates to the treatment of a tumor selected from the group consisting of pancreatic cancer, liver cancer, melanoma, colon cancer, glioblastoma, osteosarcoma, prostate cancer and breast cancer, more particularly pancreatic cancer. The inventors found a novel family compounds of formula (I) able to treat a variety of cancers by inhibiting NUPR1, a stress-inducible 82-amino-acid-long, intrinsically disordered member of the AT-hook family of chromatin proteins. Thus, the present invention relates to a compound of formula (I) for its use in the treatment of a tumor selected from the group consisting of pancreatic cancer, liver cancer, melanoma, colon cancer, glioblastoma, osteosarcoma, prostate cancer and breast cancer. In particular, the inventors tested compounds of formula (I) on four well characterized primary pancreatic cancer-derived cells 02.063 and LIPC (Basal subtype), Foic8b (derived from a liver metastasis) and HN14 (Classical subtype), as well as on other cellular lines derived f</description><language>chi ; eng</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20210723&amp;DB=EPODOC&amp;CC=CN&amp;NR=113164492A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20210723&amp;DB=EPODOC&amp;CC=CN&amp;NR=113164492A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>XIA YI</creatorcontrib><creatorcontrib>SANTOFIMIA PATRICIA</creatorcontrib><creatorcontrib>VELAZQUEZ CAMPOY ADRIAN</creatorcontrib><creatorcontrib>PENG LING</creatorcontrib><creatorcontrib>ABIAN FRANCO OLGA</creatorcontrib><creatorcontrib>IOVANNA JUAN</creatorcontrib><creatorcontrib>NEIRA JOSE LUIS</creatorcontrib><creatorcontrib>RIZZUTI BRUNO</creatorcontrib><title>NUPR1 INHIBITION FOR TREATING CANCER</title><description>The present invention relates to the treatment of a tumor selected from the group consisting of pancreatic cancer, liver cancer, melanoma, colon cancer, glioblastoma, osteosarcoma, prostate cancer and breast cancer, more particularly pancreatic cancer. The inventors found a novel family compounds of formula (I) able to treat a variety of cancers by inhibiting NUPR1, a stress-inducible 82-amino-acid-long, intrinsically disordered member of the AT-hook family of chromatin proteins. Thus, the present invention relates to a compound of formula (I) for its use in the treatment of a tumor selected from the group consisting of pancreatic cancer, liver cancer, melanoma, colon cancer, glioblastoma, osteosarcoma, prostate cancer and breast cancer. In particular, the inventors tested compounds of formula (I) on four well characterized primary pancreatic cancer-derived cells 02.063 and LIPC (Basal subtype), Foic8b (derived from a liver metastasis) and HN14 (Classical subtype), as well as on other cellular lines derived f</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFDxCw0IMlTw9PPwdPIM8fT3U3DzD1IICXJ1DPH0c1dwdvRzdg3iYWBNS8wpTuWF0twMim6uIc4euqkF-fGpxQWJyal5qSXxzn6GhsaGZiYmlkaOxsSoAQBxPyLd</recordid><startdate>20210723</startdate><enddate>20210723</enddate><creator>XIA YI</creator><creator>SANTOFIMIA PATRICIA</creator><creator>VELAZQUEZ CAMPOY ADRIAN</creator><creator>PENG LING</creator><creator>ABIAN FRANCO OLGA</creator><creator>IOVANNA JUAN</creator><creator>NEIRA JOSE LUIS</creator><creator>RIZZUTI BRUNO</creator><scope>EVB</scope></search><sort><creationdate>20210723</creationdate><title>NUPR1 INHIBITION FOR TREATING CANCER</title><author>XIA YI ; SANTOFIMIA PATRICIA ; VELAZQUEZ CAMPOY ADRIAN ; PENG LING ; ABIAN FRANCO OLGA ; IOVANNA JUAN ; NEIRA JOSE LUIS ; RIZZUTI BRUNO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN113164492A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2021</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>XIA YI</creatorcontrib><creatorcontrib>SANTOFIMIA PATRICIA</creatorcontrib><creatorcontrib>VELAZQUEZ CAMPOY ADRIAN</creatorcontrib><creatorcontrib>PENG LING</creatorcontrib><creatorcontrib>ABIAN FRANCO OLGA</creatorcontrib><creatorcontrib>IOVANNA JUAN</creatorcontrib><creatorcontrib>NEIRA JOSE LUIS</creatorcontrib><creatorcontrib>RIZZUTI BRUNO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>XIA YI</au><au>SANTOFIMIA PATRICIA</au><au>VELAZQUEZ CAMPOY ADRIAN</au><au>PENG LING</au><au>ABIAN FRANCO OLGA</au><au>IOVANNA JUAN</au><au>NEIRA JOSE LUIS</au><au>RIZZUTI BRUNO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>NUPR1 INHIBITION FOR TREATING CANCER</title><date>2021-07-23</date><risdate>2021</risdate><abstract>The present invention relates to the treatment of a tumor selected from the group consisting of pancreatic cancer, liver cancer, melanoma, colon cancer, glioblastoma, osteosarcoma, prostate cancer and breast cancer, more particularly pancreatic cancer. The inventors found a novel family compounds of formula (I) able to treat a variety of cancers by inhibiting NUPR1, a stress-inducible 82-amino-acid-long, intrinsically disordered member of the AT-hook family of chromatin proteins. Thus, the present invention relates to a compound of formula (I) for its use in the treatment of a tumor selected from the group consisting of pancreatic cancer, liver cancer, melanoma, colon cancer, glioblastoma, osteosarcoma, prostate cancer and breast cancer. In particular, the inventors tested compounds of formula (I) on four well characterized primary pancreatic cancer-derived cells 02.063 and LIPC (Basal subtype), Foic8b (derived from a liver metastasis) and HN14 (Classical subtype), as well as on other cellular lines derived f</abstract><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language chi ; eng
recordid cdi_epo_espacenet_CN113164492A
source esp@cenet
subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title NUPR1 INHIBITION FOR TREATING CANCER
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T19%3A22%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=XIA%20YI&rft.date=2021-07-23&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN113164492A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true