Application of marker for prognosis diagnosis of lung cancer and detection kit

The invention provides a biomarker for prognosis diagnosis of the lung cancer. The biomarker comprises hsa-miR-21-5p, hsa-miR-141-5p and hsa-miR-490-3p. According to the invention, the construction of a prognosis model and risk factor evaluation are carried out through screening of miRNA related to the lung cancer, prediction of target genes and functional analysis, three new miRNA markers are screened out through detection and verification of lung cancer tissues and para-carcinoma tissues, the construction of the prognosis model of the lung cancer and clinical sample verification are completed, and application of and hsa-miR-21-5p, hsa-miR-141-5p and hsa-miR-490-3p as the lung cancer prognosis diagnosis markers and a detection kit of the markers can be used for accurate prognosis, personalized treatment, disease monitoring and the like. 本发明提供了一种用于诊断肺癌预后的生物标志物，其包括hsa-miR-21-5p，hsa-miR-141-5p和hsa-miR-490-3p。本发明通过对肺癌相关miRNA筛选、靶基因的预测和功能分析，进行了预后模型的构建和风险因子评估，通过肺癌组织及癌旁组织检测验证，筛选出的三种新的miRNA标志物，并完成了肺癌预后模型的构建和临床样品验证，hs