Recombinant human erythropoietin liquid preparation

The invention discloses a recombinant human erythropoietin liquid preparation, which does not contain human albumin and has long-term storage stability, the preparation comprises recombinant human erythropoietin, betaine, a pH buffer solution, a nonionic surfactant, an osmotic pressure regulator and...

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Hauptverfasser: QU XIAO, WANG MENGGE, WU YUANYUAN, YANG YANQUN, CHENG CHUHONG, HUANG JUNLONG, WANG KANG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a recombinant human erythropoietin liquid preparation, which does not contain human albumin and has long-term storage stability, the preparation comprises recombinant human erythropoietin, betaine, a pH buffer solution, a nonionic surfactant, an osmotic pressure regulator and water, and the preparation has good stability and biological activity; and the process is simple, the operability is high, auxiliary materials are relatively easily obtained, safe and stable, and the production cost is saved. 本发明公开了一种不含有人血白蛋白的具有长期储存稳定性的重组人促红细胞生成素液体制剂,该制剂包含重组人促红细胞生成素,甜菜碱,pH缓冲溶液,非离子表面活性剂,渗透压调节剂和水,该制剂具有良好的稳定性和生物活性,便于长期储存,工艺简单,可操作性强,辅料相对易获得且安全稳定,节约了生产成本。