Synthesis method of N-methyl o-fluoroaniline
The invention relates to the field of preparation of pesticide and medical intermediates, and in particular, relates to a preparation method of N-methyl o-fluoroaniline, wherein the preparation method comprises the following steps: by taking o-fluoroaniline as a raw material and dimethyl carbonate a...
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| creator | ZHANG PU HOU YUANCHANG WU YAOJUN CHEN WENXIN ZHANG FENG WANG HAO |
| description | The invention relates to the field of preparation of pesticide and medical intermediates, and in particular, relates to a preparation method of N-methyl o-fluoroaniline, wherein the preparation method comprises the following steps: by taking o-fluoroaniline as a raw material and dimethyl carbonate as a reaction raw material and a reaction solvent, carrying out heat preservation reaction under the action of a basic catalyst; and after the reaction is finished, filtering to remove the catalyst, carrying out rectification separation on filtrate, and separating the solvent dimethyl carbonate from the product. Compared with the prior art, the novel synthesis method of N-methyl o-fluoroaniline provided by the invention has the following effective effects: only one-step reaction is needed, the selectivity is extremely high, the product quality is good, the selected methylation reagent dimethyl carbonate is low in toxicity, green and safe, the output of three wastes is low, and the novel synthesis method of N-methyl |
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Compared with the prior art, the novel synthesis method of N-methyl o-fluoroaniline provided by the invention has the following effective effects: only one-step reaction is needed, the selectivity is extremely high, the product quality is good, the selected methylation reagent dimethyl carbonate is low in toxicity, green and safe, the output of three wastes is low, and the novel synthesis method of N-methyl</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNAJrswryUgtzixWyE0tychPUchPU_DTBbErcxTyddNySvOL8hPzMnMy81J5GFjTEnOKU3mhNDeDoptriLOHbmpBfnxqcUFicmpeakm8s5-hoZGFqaGpoYWjMTFqAJgaKdQ</recordid><startdate>20210528</startdate><enddate>20210528</enddate><creator>ZHANG PU</creator><creator>HOU YUANCHANG</creator><creator>WU YAOJUN</creator><creator>CHEN WENXIN</creator><creator>ZHANG FENG</creator><creator>WANG HAO</creator><scope>EVB</scope></search><sort><creationdate>20210528</creationdate><title>Synthesis method of N-methyl o-fluoroaniline</title><author>ZHANG PU ; HOU YUANCHANG ; WU YAOJUN ; CHEN WENXIN ; ZHANG FENG ; WANG HAO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN112851518A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2021</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>ZHANG PU</creatorcontrib><creatorcontrib>HOU YUANCHANG</creatorcontrib><creatorcontrib>WU YAOJUN</creatorcontrib><creatorcontrib>CHEN WENXIN</creatorcontrib><creatorcontrib>ZHANG FENG</creatorcontrib><creatorcontrib>WANG HAO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ZHANG PU</au><au>HOU YUANCHANG</au><au>WU YAOJUN</au><au>CHEN WENXIN</au><au>ZHANG FENG</au><au>WANG HAO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Synthesis method of N-methyl o-fluoroaniline</title><date>2021-05-28</date><risdate>2021</risdate><abstract>The invention relates to the field of preparation of pesticide and medical intermediates, and in particular, relates to a preparation method of N-methyl o-fluoroaniline, wherein the preparation method comprises the following steps: by taking o-fluoroaniline as a raw material and dimethyl carbonate as a reaction raw material and a reaction solvent, carrying out heat preservation reaction under the action of a basic catalyst; and after the reaction is finished, filtering to remove the catalyst, carrying out rectification separation on filtrate, and separating the solvent dimethyl carbonate from the product. 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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY METALLURGY ORGANIC CHEMISTRY |
| title | Synthesis method of N-methyl o-fluoroaniline |
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