Method for detecting antioxidant degradation product in sodium chloride injection of levofloxacin lactate

Method for detecting antioxidant degradation product in sodium chloride injection of levofloxacin lactate

The invention provides a method for detecting an antioxidant degradation product in a sodium chloride injection of levofloxacin lactate. The sodium chloride injection of levofloxacin lactate is treated by adopting solid-phase extraction, and the step of cleaning the levofloxacin lactate on a solid-p...

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Hauptverfasser: YANG JUNMIAN, LI BIAO, HAN QIANRU, ZONG YINGYING, CUI XUEMEI, GUO YAWEI, LUO HUIRU, MA MINGZHUO
Format: Patent
Sprache:chi ; eng
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INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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creator YANG JUNMIAN
LI BIAO
HAN QIANRU
ZONG YINGYING
CUI XUEMEI
GUO YAWEI
LUO HUIRU
MA MINGZHUO
description The invention provides a method for detecting an antioxidant degradation product in a sodium chloride injection of levofloxacin lactate. The sodium chloride injection of levofloxacin lactate is treated by adopting solid-phase extraction, and the step of cleaning the levofloxacin lactate on a solid-phase extraction column by using an acetic acid solution with a specific concentration is added before elution, so that the interference of the levofloxacin lactate on the detection of 2, 4-di-tert-butylphenol and 3, 5-di-tert-butyl-4-hydroxyphenylpropionic acid is avoided; and then ACQUITY UPLC BEHC18 is adopted, an acetonitrile-aqueous solution with the volume ratio of 70: 30 is taken as a mobile phase, and detection is carried out under the detection wavelength of 280 nm. The method has the advantages of high sensitivity, accurate quantification and short detection time, and accurate and quantitative detection of 3, 5-di-tert-butyl-4-hydroxyphenylpropionic acid and 2, 4-di-tert-butylphenol in the sodium chloride
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subjects INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
title Method for detecting antioxidant degradation product in sodium chloride injection of levofloxacin lactate
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