Methylation marker combination for early screening of prostatic cancer and screening method

The invention discloses a methylation marker combination for early screening of prostatic cancer and a screening method, relates to the field of bioinformatics, and mainly provides specific methylation markers (cg26140475, cg24891312, cg24522654, cg21359747, cg03254336, cg12697139 and cg19034132) re...

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Bibliographische Detailangaben
Hauptverfasser:	YUAN HAINING, LI CHAO, PU YIYI, WANG XIAOJU
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention discloses a methylation marker combination for early screening of prostatic cancer and a screening method, relates to the field of bioinformatics, and mainly provides specific methylation markers (cg26140475, cg24891312, cg24522654, cg21359747, cg03254336, cg12697139 and cg19034132) related to early diagnosis of prostatic cancer and obtained by screening in databases, and a model established on the basis of the markers. The method is based on the public databases (TCGA and GEO), early diagnosis markers are specifically identified through accurate cancer sample classification, and then a series of cancer specific markers are finally identified by comparing the markers of different cancers. 本发明公开了一种用于前列腺癌早期筛查的甲基化标志物组合及筛选方法，涉及生物信息学领域，主要提供了利用数据库筛选得到的前列腺癌早期诊断相关的特异性甲基化标志物(cg26140475,cg24891312,cg24522654,cg21359747,cg03254336,cg12697139,cg19034132)及基于标志物建立的模型。该方法基于公共数据库(TCGA、GEO)，并且通过精准的癌症样本分类，针对性的鉴定出早期诊断标志物，之后通过对比不同癌症的标志物，最终鉴定出一系列癌症特异性的标志物。