Analysis method for measuring degradation products of oral solution containing methylparaben by HPLC technology
The invention belongs to the field of analytical chemistry, and particularly relates to an analysis method for measuring degradation products of an oral solution containing methylparaben by an HPLC technology. Octadecylsilane chemically bonded silica is selected as a filler, and a mixed solvent of a...
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| creator | ZHAO HANG LI XIN TU FANGFANG ZHOU LIANG XU BINGYONG NI SHENG XIA JINQIANG JIANG WEIBIN TANG LILING CHEN HONGXIANG BU HUARONG CHENG FANGSHENG ZHANG LIHUA LIAO ZHIXIONG DAI SHOUFENG |
| description | The invention belongs to the field of analytical chemistry, and particularly relates to an analysis method for measuring degradation products of an oral solution containing methylparaben by an HPLC technology. Octadecylsilane chemically bonded silica is selected as a filler, and a mixed solvent of an organic phase and a buffer solution is used as a mobile phase for gradient elution. Degradation impurities are p-hydroxybenzoic acid and p-benzoquinone, the methyl hydroxybenzoate and degradation products thereof in the oral solution containing the methyl hydroxybenzoate can be rapidly separated by adopting the method, the detection method is high in specificity, high in precision and high in accuracy, a solvent does not interfere with determination in detection, and a detection result is reliable and accurate. And the method has extremely important significance for realizing quality control of the oral solution containing methylparaben.
本发明属于分析化学领域，具体涉及一种HPLC法测定测定含羟苯甲酯类口服溶液降解产物的分析方法，选择十八烷基硅烷键合硅胶为填料，以有机相与缓冲液混合溶剂作 |
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本发明属于分析化学领域，具体涉及一种HPLC法测定测定含羟苯甲酯类口服溶液降解产物的分析方法，选择十八烷基硅烷键合硅胶为填料，以有机相与缓冲液混合溶剂作</description><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>PHYSICS</subject><subject>TESTING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjEEKwjAQRbtxIeodxgMItgq6LUXpQsSF-zJNJm0gzoQkXeT2WvEArv6H999fFlIzuhxthBelUTQYCZ-KcQqWB9A0BNSYrDD4IHpSKYIYkIAOorjpS5RwQsuzML9k5zFgTwx9hvZxayCRGlmcDHldLAy6SJtfrort9fJs2h156Sh6VMSUuuZeltXpeK72VX34Z_MGcfJDjQ</recordid><startdate>20210504</startdate><enddate>20210504</enddate><creator>ZHAO HANG</creator><creator>LI XIN</creator><creator>TU FANGFANG</creator><creator>ZHOU LIANG</creator><creator>XU BINGYONG</creator><creator>NI SHENG</creator><creator>XIA JINQIANG</creator><creator>JIANG WEIBIN</creator><creator>TANG LILING</creator><creator>CHEN HONGXIANG</creator><creator>BU HUARONG</creator><creator>CHENG FANGSHENG</creator><creator>ZHANG LIHUA</creator><creator>LIAO ZHIXIONG</creator><creator>DAI SHOUFENG</creator><scope>EVB</scope></search><sort><creationdate>20210504</creationdate><title>Analysis method for measuring degradation products of oral solution containing methylparaben by HPLC technology</title><author>ZHAO HANG ; LI XIN ; TU FANGFANG ; ZHOU LIANG ; XU BINGYONG ; NI SHENG ; XIA JINQIANG ; JIANG WEIBIN ; TANG LILING ; CHEN HONGXIANG ; BU HUARONG ; CHENG FANGSHENG ; ZHANG LIHUA ; LIAO ZHIXIONG ; DAI SHOUFENG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN112748202A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2021</creationdate><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>PHYSICS</topic><topic>TESTING</topic><toplevel>online_resources</toplevel><creatorcontrib>ZHAO HANG</creatorcontrib><creatorcontrib>LI XIN</creatorcontrib><creatorcontrib>TU FANGFANG</creatorcontrib><creatorcontrib>ZHOU LIANG</creatorcontrib><creatorcontrib>XU BINGYONG</creatorcontrib><creatorcontrib>NI SHENG</creatorcontrib><creatorcontrib>XIA JINQIANG</creatorcontrib><creatorcontrib>JIANG WEIBIN</creatorcontrib><creatorcontrib>TANG LILING</creatorcontrib><creatorcontrib>CHEN HONGXIANG</creatorcontrib><creatorcontrib>BU HUARONG</creatorcontrib><creatorcontrib>CHENG FANGSHENG</creatorcontrib><creatorcontrib>ZHANG LIHUA</creatorcontrib><creatorcontrib>LIAO ZHIXIONG</creatorcontrib><creatorcontrib>DAI SHOUFENG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ZHAO HANG</au><au>LI XIN</au><au>TU FANGFANG</au><au>ZHOU LIANG</au><au>XU BINGYONG</au><au>NI SHENG</au><au>XIA JINQIANG</au><au>JIANG WEIBIN</au><au>TANG LILING</au><au>CHEN HONGXIANG</au><au>BU HUARONG</au><au>CHENG FANGSHENG</au><au>ZHANG LIHUA</au><au>LIAO ZHIXIONG</au><au>DAI SHOUFENG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Analysis method for measuring degradation products of oral solution containing methylparaben by HPLC technology</title><date>2021-05-04</date><risdate>2021</risdate><abstract>The invention belongs to the field of analytical chemistry, and particularly relates to an analysis method for measuring degradation products of an oral solution containing methylparaben by an HPLC technology. Octadecylsilane chemically bonded silica is selected as a filler, and a mixed solvent of an organic phase and a buffer solution is used as a mobile phase for gradient elution. Degradation impurities are p-hydroxybenzoic acid and p-benzoquinone, the methyl hydroxybenzoate and degradation products thereof in the oral solution containing the methyl hydroxybenzoate can be rapidly separated by adopting the method, the detection method is high in specificity, high in precision and high in accuracy, a solvent does not interfere with determination in detection, and a detection result is reliable and accurate. And the method has extremely important significance for realizing quality control of the oral solution containing methylparaben.
本发明属于分析化学领域，具体涉及一种HPLC法测定测定含羟苯甲酯类口服溶液降解产物的分析方法，选择十八烷基硅烷键合硅胶为填料，以有机相与缓冲液混合溶剂作</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING PHYSICS TESTING |
| title | Analysis method for measuring degradation products of oral solution containing methylparaben by HPLC technology |
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