Preparation method of double-drug-loading thermosensitive liposome and application thereof
The invention relates to a preparation method of a double-drug-loading thermosensitive liposome and application thereof. Early diagnosis of tumors can be quickly realized, effective absorption of tumor cells to drugs is increased, the half-life period of the drugs in vivo is prolonged, and bioavaila...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | chi ; eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | XU YUE WU DEQIAO XU XIA ZHANG ZHENZHONG ZHANG NAN GAO MING XIN XIANGYING FENG NANNAN ZHANG JUNWEI HUO PENGCHAO ZHANG YAN CHEN HUI FENG QUANLING |
| description | The invention relates to a preparation method of a double-drug-loading thermosensitive liposome and application thereof. Early diagnosis of tumors can be quickly realized, effective absorption of tumor cells to drugs is increased, the half-life period of the drugs in vivo is prolonged, and bioavailability of the drugs is improved. According to the technical scheme, the preparation method comprises the steps that dipalmitoyl phosphatidylcholine, cholesterol, phospholipid polyethylene glycol-RGD peptide, 2-methoxyestradiol and indocyanine green are weighed in a round-bottom flask, then the mixture is dissolved in a mixed solution of chloroform and methanol to be subjected to ultrasonic dissolution, and a PBS solution is added in the round-bottom flask to be subjected to hydration treatment on a rotary evaporator at room temperature; finally, the double-drug-loading thermosensitive liposome is obtained after polycarbonate membrane extrusion. The preparation method of the double-drug-loading thermosensitive lipos |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN112675129A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN112675129A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN112675129A3</originalsourceid><addsrcrecordid>eNqNzLEKwjAURuEsDqK-w_UBOrSi4ihFcRIHJ5dybf60gSQ3JKnPL6IP4HSWjzNXj1tC5MTFSiCPMoomMaRlejpUOk1D5YS1DQOVEclLRsi22BfI2ShZPIiDJo7R2f67-UCIWaqZYZex-nWh1ufTvb1UiNIhR-4RULr2WtfNbr-tm8Nx8495A6QAPAo</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Preparation method of double-drug-loading thermosensitive liposome and application thereof</title><source>esp@cenet</source><creator>XU YUE ; WU DEQIAO ; XU XIA ; ZHANG ZHENZHONG ; ZHANG NAN ; GAO MING ; XIN XIANGYING ; FENG NANNAN ; ZHANG JUNWEI ; HUO PENGCHAO ; ZHANG YAN ; CHEN HUI ; FENG QUANLING</creator><creatorcontrib>XU YUE ; WU DEQIAO ; XU XIA ; ZHANG ZHENZHONG ; ZHANG NAN ; GAO MING ; XIN XIANGYING ; FENG NANNAN ; ZHANG JUNWEI ; HUO PENGCHAO ; ZHANG YAN ; CHEN HUI ; FENG QUANLING</creatorcontrib><description>The invention relates to a preparation method of a double-drug-loading thermosensitive liposome and application thereof. Early diagnosis of tumors can be quickly realized, effective absorption of tumor cells to drugs is increased, the half-life period of the drugs in vivo is prolonged, and bioavailability of the drugs is improved. According to the technical scheme, the preparation method comprises the steps that dipalmitoyl phosphatidylcholine, cholesterol, phospholipid polyethylene glycol-RGD peptide, 2-methoxyestradiol and indocyanine green are weighed in a round-bottom flask, then the mixture is dissolved in a mixed solution of chloroform and methanol to be subjected to ultrasonic dissolution, and a PBS solution is added in the round-bottom flask to be subjected to hydration treatment on a rotary evaporator at room temperature; finally, the double-drug-loading thermosensitive liposome is obtained after polycarbonate membrane extrusion. The preparation method of the double-drug-loading thermosensitive lipos</description><language>chi ; eng</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210420&DB=EPODOC&CC=CN&NR=112675129A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76419</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210420&DB=EPODOC&CC=CN&NR=112675129A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>XU YUE</creatorcontrib><creatorcontrib>WU DEQIAO</creatorcontrib><creatorcontrib>XU XIA</creatorcontrib><creatorcontrib>ZHANG ZHENZHONG</creatorcontrib><creatorcontrib>ZHANG NAN</creatorcontrib><creatorcontrib>GAO MING</creatorcontrib><creatorcontrib>XIN XIANGYING</creatorcontrib><creatorcontrib>FENG NANNAN</creatorcontrib><creatorcontrib>ZHANG JUNWEI</creatorcontrib><creatorcontrib>HUO PENGCHAO</creatorcontrib><creatorcontrib>ZHANG YAN</creatorcontrib><creatorcontrib>CHEN HUI</creatorcontrib><creatorcontrib>FENG QUANLING</creatorcontrib><title>Preparation method of double-drug-loading thermosensitive liposome and application thereof</title><description>The invention relates to a preparation method of a double-drug-loading thermosensitive liposome and application thereof. Early diagnosis of tumors can be quickly realized, effective absorption of tumor cells to drugs is increased, the half-life period of the drugs in vivo is prolonged, and bioavailability of the drugs is improved. According to the technical scheme, the preparation method comprises the steps that dipalmitoyl phosphatidylcholine, cholesterol, phospholipid polyethylene glycol-RGD peptide, 2-methoxyestradiol and indocyanine green are weighed in a round-bottom flask, then the mixture is dissolved in a mixed solution of chloroform and methanol to be subjected to ultrasonic dissolution, and a PBS solution is added in the round-bottom flask to be subjected to hydration treatment on a rotary evaporator at room temperature; finally, the double-drug-loading thermosensitive liposome is obtained after polycarbonate membrane extrusion. The preparation method of the double-drug-loading thermosensitive lipos</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNzLEKwjAURuEsDqK-w_UBOrSi4ihFcRIHJ5dybf60gSQ3JKnPL6IP4HSWjzNXj1tC5MTFSiCPMoomMaRlejpUOk1D5YS1DQOVEclLRsi22BfI2ShZPIiDJo7R2f67-UCIWaqZYZex-nWh1ufTvb1UiNIhR-4RULr2WtfNbr-tm8Nx8495A6QAPAo</recordid><startdate>20210420</startdate><enddate>20210420</enddate><creator>XU YUE</creator><creator>WU DEQIAO</creator><creator>XU XIA</creator><creator>ZHANG ZHENZHONG</creator><creator>ZHANG NAN</creator><creator>GAO MING</creator><creator>XIN XIANGYING</creator><creator>FENG NANNAN</creator><creator>ZHANG JUNWEI</creator><creator>HUO PENGCHAO</creator><creator>ZHANG YAN</creator><creator>CHEN HUI</creator><creator>FENG QUANLING</creator><scope>EVB</scope></search><sort><creationdate>20210420</creationdate><title>Preparation method of double-drug-loading thermosensitive liposome and application thereof</title><author>XU YUE ; WU DEQIAO ; XU XIA ; ZHANG ZHENZHONG ; ZHANG NAN ; GAO MING ; XIN XIANGYING ; FENG NANNAN ; ZHANG JUNWEI ; HUO PENGCHAO ; ZHANG YAN ; CHEN HUI ; FENG QUANLING</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN112675129A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2021</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>XU YUE</creatorcontrib><creatorcontrib>WU DEQIAO</creatorcontrib><creatorcontrib>XU XIA</creatorcontrib><creatorcontrib>ZHANG ZHENZHONG</creatorcontrib><creatorcontrib>ZHANG NAN</creatorcontrib><creatorcontrib>GAO MING</creatorcontrib><creatorcontrib>XIN XIANGYING</creatorcontrib><creatorcontrib>FENG NANNAN</creatorcontrib><creatorcontrib>ZHANG JUNWEI</creatorcontrib><creatorcontrib>HUO PENGCHAO</creatorcontrib><creatorcontrib>ZHANG YAN</creatorcontrib><creatorcontrib>CHEN HUI</creatorcontrib><creatorcontrib>FENG QUANLING</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>XU YUE</au><au>WU DEQIAO</au><au>XU XIA</au><au>ZHANG ZHENZHONG</au><au>ZHANG NAN</au><au>GAO MING</au><au>XIN XIANGYING</au><au>FENG NANNAN</au><au>ZHANG JUNWEI</au><au>HUO PENGCHAO</au><au>ZHANG YAN</au><au>CHEN HUI</au><au>FENG QUANLING</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Preparation method of double-drug-loading thermosensitive liposome and application thereof</title><date>2021-04-20</date><risdate>2021</risdate><abstract>The invention relates to a preparation method of a double-drug-loading thermosensitive liposome and application thereof. Early diagnosis of tumors can be quickly realized, effective absorption of tumor cells to drugs is increased, the half-life period of the drugs in vivo is prolonged, and bioavailability of the drugs is improved. According to the technical scheme, the preparation method comprises the steps that dipalmitoyl phosphatidylcholine, cholesterol, phospholipid polyethylene glycol-RGD peptide, 2-methoxyestradiol and indocyanine green are weighed in a round-bottom flask, then the mixture is dissolved in a mixed solution of chloroform and methanol to be subjected to ultrasonic dissolution, and a PBS solution is added in the round-bottom flask to be subjected to hydration treatment on a rotary evaporator at room temperature; finally, the double-drug-loading thermosensitive liposome is obtained after polycarbonate membrane extrusion. The preparation method of the double-drug-loading thermosensitive lipos</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | chi ; eng |
| recordid | cdi_epo_espacenet_CN112675129A |
| source | esp@cenet |
| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Preparation method of double-drug-loading thermosensitive liposome and application thereof |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T01%3A04%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=XU%20YUE&rft.date=2021-04-20&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN112675129A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |