Separation method of L-alanine isopropyl ester hydrochloride and enantiomer thereof
The invention discloses a separation method of L-alanine isopropyl ester hydrochloride and an enantiomer thereof. The separation method comprises the following steps: under alkaline conditions, derivatizing the L-alanine isopropyl ester hydrochloride and the enantiomer thereof by using a GITC soluti...
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| creator | LIAO ZHENGHUA ZHANG HONGFEI SHANG JINFENG GUO SAI |
| description | The invention discloses a separation method of L-alanine isopropyl ester hydrochloride and an enantiomer thereof. The separation method comprises the following steps: under alkaline conditions, derivatizing the L-alanine isopropyl ester hydrochloride and the enantiomer thereof by using a GITC solution; and separating and detecting the derivatized L-alanine isopropyl ester hydrochloride and isomers thereof by adopting an HPLC method. According to the separation method, the L-alanine isopropyl ester hydrochloride and the enantiomer D-alanine isopropyl ester hydrochloride thereof can be effectively separated, and the content of the enantiomer can be accurately determined. According to the method, a specific reversed-phase method and an isocratic elution mode are adopted, the method is simple, easy to operate, good in peak pattern and qualified in separation degree, and methodology verification shows that the method is high in specificity, high in sensitivity and good in accuracy and linearity.
本发明公开了一种L-丙氨酸异丙酯盐酸 |
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本发明公开了一种L-丙氨酸异丙酯盐酸</description><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>PHYSICS</subject><subject>TESTING</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNi7EKwjAURbM4iPoPzw8oWCPuUhQHcal7eTS3JJC-F5Is_Xs7-AFOZzjnbE3fI3HmGlRoRvXqSCd6NRxZgoBC0ZQ1LZFQKjL5xWUdfdQcHIjFEYRl3edVVo8MnfZmM3EsOPy4M8fH_dM9GyQdUBKPENShe7ft-WpPtr3c7D_NF4yMONc</recordid><startdate>20210409</startdate><enddate>20210409</enddate><creator>LIAO ZHENGHUA</creator><creator>ZHANG HONGFEI</creator><creator>SHANG JINFENG</creator><creator>GUO SAI</creator><scope>EVB</scope></search><sort><creationdate>20210409</creationdate><title>Separation method of L-alanine isopropyl ester hydrochloride and enantiomer thereof</title><author>LIAO ZHENGHUA ; ZHANG HONGFEI ; SHANG JINFENG ; GUO SAI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN112630314A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2021</creationdate><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>PHYSICS</topic><topic>TESTING</topic><toplevel>online_resources</toplevel><creatorcontrib>LIAO ZHENGHUA</creatorcontrib><creatorcontrib>ZHANG HONGFEI</creatorcontrib><creatorcontrib>SHANG JINFENG</creatorcontrib><creatorcontrib>GUO SAI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LIAO ZHENGHUA</au><au>ZHANG HONGFEI</au><au>SHANG JINFENG</au><au>GUO SAI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Separation method of L-alanine isopropyl ester hydrochloride and enantiomer thereof</title><date>2021-04-09</date><risdate>2021</risdate><abstract>The invention discloses a separation method of L-alanine isopropyl ester hydrochloride and an enantiomer thereof. The separation method comprises the following steps: under alkaline conditions, derivatizing the L-alanine isopropyl ester hydrochloride and the enantiomer thereof by using a GITC solution; and separating and detecting the derivatized L-alanine isopropyl ester hydrochloride and isomers thereof by adopting an HPLC method. According to the separation method, the L-alanine isopropyl ester hydrochloride and the enantiomer D-alanine isopropyl ester hydrochloride thereof can be effectively separated, and the content of the enantiomer can be accurately determined. According to the method, a specific reversed-phase method and an isocratic elution mode are adopted, the method is simple, easy to operate, good in peak pattern and qualified in separation degree, and methodology verification shows that the method is high in specificity, high in sensitivity and good in accuracy and linearity.
本发明公开了一种L-丙氨酸异丙酯盐酸</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING PHYSICS TESTING |
| title | Separation method of L-alanine isopropyl ester hydrochloride and enantiomer thereof |
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