Bionic mineralized collagen gel and preparation method and application thereof

The invention provides bionic mineralized collagen gel and a preparation method and application thereof, and belongs to the technical field of bionic materials. Polyaspartic acid is adopted as a stabilizer, a mineralization solution containing calcium ions and phosphate ions can form amorphous calcium phosphate nano-clusters, after collagen hydrogel is mixed with the amorphous calcium phosphate nano-clusters, the amorphous calcium phosphate nano-clusters can enter collagen fibrils in the collagen hydrogel and be combined with free carboxyl, then nucleating and phase change are performed to form hydroxyapatite, the hydroxyapatite grows in order in the long axis direction of the collagen fibrils, and mineralization in the collagen fibrils in the collagen gel is achieved. 本发明提供了一种仿生矿化胶原凝胶及其制备方法和应用，属于仿生材料技术领域。本发明通过采用以聚天冬氨酸为稳定剂，含有钙离子和磷酸根离子的矿化液，会形成不定型磷酸钙纳米簇，将胶原水凝胶与其混合后，不定型磷酸钙纳米簇可以进入胶原水凝胶中的胶原原纤维的内部，与游离的羧基结合，进而成核、相变成为羟基磷灰石，并沿胶原原纤维长轴方向有序生长，实现胶原凝胶中胶原纤维内矿化。