TRIMERIC POLYPEPTIDE COMPLEXES AND USES THEREOF

The invention relates to tumor-targeted trimeric polypeptides based on the homotrimerization region from collagen XV or XVIII and which contain domains capable of specifically binding to and activating receptors of the TNFR family of costimulatory receptors as well as to the uses thereof in the treatment of cancer. 本发明涉及基于来自胶原蛋白XV或XVIII的同三聚体化区域的靶向肿瘤的三聚体多肽以及其在癌症治疗中的用途，并且所述三聚体多肽包含能够特异性结合并活化共刺激受体的TNFR家族的受体的结构域。