Synthesis method of 4-(2, 2, 2-trichloroethyl)-beta-lactam derivative

The invention relates to a preparation method of a 4-(2, 2, 2-trichloroethyl)-beta-lactam derivative, which comprises the following steps: reacting a substituted N-quinoline-3-butene amide derivativein trichloromethane at 100-120 DEG C under the actions of an oxidant and a copper salt catalyst, and completely reacting to obtain the 4-(2, 2, 2-trichloroethyl)-beta-lactam derivative. According to the method provided by the invention, various 4-(2, 2, 2-trichloroethyl)-beta-lactam derivatives can be obtained with high yield. The method has the advantages of mild reaction conditions, simple reaction operation and simple post-treatment process, and is suitable for large-scale production. 本发明涉及一种4-(2,2,2-三氯乙基)-β-内酰胺衍生物的制备方法，将取代N-喹啉-3-丁烯酰胺衍生物在氧化剂和铜盐催化剂的作用下，在三氯甲烷中于100～120℃下反应，反应完全后得到4-(2,2,2-三氯乙基)-β-内酰胺衍生物。按照本发明的方法可以高收率的得到多种4-(2,2,2-三氯乙基)-β-内酰胺衍生物。本发明反应条件较温和、反应操作和后处理过程简单，适合于规模化生产。