Purification method for chlorin e6

The invention belongs to the field of medicines, and particularly relates to a purification method for chlorin e6 . The purification method comprises the following steps: addition of alkali for salt formation and addition of acid for dissociation. The purification method comprises the following spec...

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Bibliographische Detailangaben
Hauptverfasser: ZHANG TAO, SONG ZHIGUO, HUANG YUSHA, XIAO FENGPING, WU SIDAN, PANG YUHUA, LI LIANG
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention belongs to the field of medicines, and particularly relates to a purification method for chlorin e6 . The purification method comprises the following steps: addition of alkali for salt formation and addition of acid for dissociation. The purification method comprises the following specific steps: namely dissolving a crude chlorin e6 product into a salt-forming solvent, adding alkalito form salt, conducting crystallizing and filtering, then dissolving a filter cake into a dissociation solvent, adding acid for dissociation, and performing crystallizing to obtain high-purity chlorin e6. The method has the advantages of simple and stable process operation and high purification efficiency. 本发明属于医药领域,具体而言涉及一种二氢卟吩e6的纯化方法。该纯化方法包括加碱成盐和加酸解离的步骤,即将二氢卟吩e6粗品溶于成盐溶剂中,加入碱成盐,析晶过滤,然后将滤饼溶于解离溶剂中,加入酸解离,析晶后得到高纯度二氢卟吩e6。该方法具有工艺操作简单稳定、提纯效率高的优点。