OLIGONUCLEOTIDES COMPRISING PHOSPHOROTRITHIOATE INTERNUCLEOSIDE LINKAGE

The present invention relates to an oligonucleotide comprising at least one phosphorotrithioate internucleoside linkage of formula (I), wherein (A1), (A2) and R are as defined in the description and in the claim. The oligonucleotide of the invention can be used as a medicament. 本发明涉及一种寡核苷酸，其包含至少一个式(...

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Bibliographische Detailangaben
Hauptverfasser:	SCHAEUBLIN ADRIAN, DUSCHMALE JOERG J. A, DUSCHMALE MARTINA BRIGITTE, KOCH TROELS, BLEICHER KONRAD, LI MEILING, KOLLER ERICH
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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Beschreibung
Zusammenfassung:	The present invention relates to an oligonucleotide comprising at least one phosphorotrithioate internucleoside linkage of formula (I), wherein (A1), (A2) and R are as defined in the description and in the claim. The oligonucleotide of the invention can be used as a medicament. 本发明涉及一种寡核苷酸，其包含至少一个式(I)的三硫代磷酸酯核苷间键其中(A1)、(A2)和R如说明书和权利要求书中所定义。本发明所述的寡核苷酸可用作药物。