Paclitaxel-platinum (IV) compound, intermediate, preparation method and application

The invention discloses a paclitaxel platinum (IV) compound, an intermediate, a preparation method and application. The structural formula of the compound is shown in the specification, wherein a partof the formula shown in the specification is cis-platinum, carboplatin, heptplatinum, nedaplatin, oxaliplatin or miriplatin, R1 and R2 are independently -CnH2n-, and n is an integer and is greater than or equal to 1 and less than or equal to 10. Compared with the prior art, the compound has the following advantages: (1) the compound provided by the invention improves the defect of poor water solubility of paclitaxel, improves the bioavailability of paclitaxel, and reduces the toxic and side effects of traditional platinum drugs; (2) the compound is used for treating cancers, the IC50 value ofthe compound is obviously lower than that of paclitaxel, cisplatin (or oxaliplatin) and the compound is administrated in a combined manner, so that the compound has better anti-proliferative abilityto cancer cells, has smalle