Clindamycin phosphoric acid gel composition and preparation method thereof

The invention provides a preparation composition of a clindamycin phosphate gel. The composition disclosed by the invention comprises the following ingredients: each 10g of clindamycin phosphate gel contains 0.05-0.15g of clindamycin phosphate, 0.1-0.2g of carbomer (980NF), 0.7-1.2g of glycerin, 0.005-0.01g of methylparaben, 0.005-0.01g of propylparaben, 0.005-0.2g of triethanolamine and 0.01-0.02g of trehalose. In the composition disclosed by the invention, each ingredient performs a synergistic effect, and the clindamycin phosphate gel which is finally prepared has higher stability. 本发明提供了一种克林霉素磷酸酯凝胶剂的制剂组合物。本发明所述的组合物包括以下成分：每10g克林霉素磷酸酯凝胶剂中含克林霉素磷酸酯0.05～0.15g，卡波姆(980NF)0.1～0.2g、甘油0.7～1.2g，尼泊金甲酯0.005～0.01g，尼泊金丙酯0.005～0.01g，三乙醇胺0.005g～0.2g，海藻糖0.01～0.02g。本发明中各组分协同作用，最终制备得到的克林霉素磷酸酯凝脂稳定性更高。