Application of ASTE1 in detection of esophageal squamous cell carcinoma

The invention belongs to the technical field of biomedicine and molecular biology, and relates to application of ASTE1 in preparation of an esophageal squamous cell carcinoma detection kit. A differential gene expression profile between an asymptomatic population and esophageal squamous cell carcino...

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Hauptverfasser:	WANG LIDONG, WANG XIANZENG, FAN ZONGMIN, YILIYAER XIAHEDING, LEI LINGLING, MAO WEIMIN, SONG XIN, ZHAO XUEKE, XU RUIHUA
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention belongs to the technical field of biomedicine and molecular biology, and relates to application of ASTE1 in preparation of an esophageal squamous cell carcinoma detection kit. A differential gene expression profile between an asymptomatic population and esophageal squamous cell carcinoma tissues is established by using a gene chip kit, the level of ASTE1mRNA in the asymptomatic population and the esophageal squamous cell carcinoma tissues is measured by using a real-time quantitative PCR technology, and the content of ASTE1 in serum samples of the asymptomatic population and theesophageal squamous cell carcinoma patients is detected by using a sandwich ELISA method. Results prove that the ASTE1 can be used as a novel serum marker for esophageal squamous cell carcinoma, can be used for further preparing an ELISA diagnostic kit for detecting esophageal squamous cell carcinoma, and provides important reference information for diagnosis of preoperative or early squamous cellcarcinoma. 本发明属于生物医学和分子生物