Arylmethylamino-substituted nitrogen heterocyclic compound as well as preparation method and application thereof
The invention aims to solve the technical problem of providing an arylmethylamino-substituted nitrogen heterocyclic compound as shown in a formula (III), a synthesis method thereof and application ofthe compound in preparation of antitumor drugs. The method comprises the steps of mixing a triazine c...
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| creator | PAN ZEXI CUI DONGMEI SU CHENGWU |
| description | The invention aims to solve the technical problem of providing an arylmethylamino-substituted nitrogen heterocyclic compound as shown in a formula (III), a synthesis method thereof and application ofthe compound in preparation of antitumor drugs. The method comprises the steps of mixing a triazine compound shown in a formula (I) and arylmethanol shown in a formula (II), adding the mixture into asolvent, stirring and reacting for 8-14 hours at the temperature of 100-140 DEG C under the action of a ruthenium catalyst and an alkaline substance, and after the reaction is finished, carrying out aftertreatment on the obtained reaction solution to obtain the arylmethylamino-substituted triazine compound shown in the formula (III). The compound is high in application value, and a practical, efficient and environment-friendly method is provided for high-throughput screening of arylmethylamino-substituted triazine skeleton small molecule drugs and synthesis of complex natural products.
本发明要解决的技术问题是提供一种式(III)所示芳甲胺取代的氮杂环 |
| format | Patent |
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本发明要解决的技术问题是提供一种式(III)所示芳甲胺取代的氮杂环</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Arylmethylamino-substituted nitrogen heterocyclic compound as well as preparation method and application thereof |
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