Arylmethylamino-substituted nitrogen heterocyclic compound as well as preparation method and application thereof

The invention aims to solve the technical problem of providing an arylmethylamino-substituted nitrogen heterocyclic compound as shown in a formula (III), a synthesis method thereof and application ofthe compound in preparation of antitumor drugs. The method comprises the steps of mixing a triazine compound shown in a formula (I) and arylmethanol shown in a formula (II), adding the mixture into asolvent, stirring and reacting for 8-14 hours at the temperature of 100-140 DEG C under the action of a ruthenium catalyst and an alkaline substance, and after the reaction is finished, carrying out aftertreatment on the obtained reaction solution to obtain the arylmethylamino-substituted triazine compound shown in the formula (III). The compound is high in application value, and a practical, efficient and environment-friendly method is provided for high-throughput screening of arylmethylamino-substituted triazine skeleton small molecule drugs and synthesis of complex natural products. 本发明要解决的技术问题是提供一种式(III)所示芳甲胺取代的氮杂环