BIOCOMPATIBLE COPOLYMER CONTAINING MULTIPLE ACTIVE AGENT MOLECULES

The present disclosure relates to the delivery of active agents, e.g., drug substances, using as carriers for their delivery biocompatible copolymers comprising side chain-linked amino acids having active agents bound to their alpha-amino and/or alpha-carboxyl groups, either directly or via linker m...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: HITZ HANS, HACKEBEIL MICHAEL, PANIGHETTI DAVIDE, GERATHS CHRISTIAN, THOMMEN CHRISTOPHE
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The present disclosure relates to the delivery of active agents, e.g., drug substances, using as carriers for their delivery biocompatible copolymers comprising side chain-linked amino acids having active agents bound to their alpha-amino and/or alpha-carboxyl groups, either directly or via linker molecules. The active agent-containing copolymers can be functionalized to contain cell type- or tissue type-specific targeting moieties. 本公开涉及使用包含侧链连接的氨基酸的生物相容性共聚物作为用于活性剂递送的载体来递送所述活性剂,例如药物,所述侧链连接的氨基酸直接或经由接头分子使所述活性剂结合至其α-氨基和/或α-羧基。可以将含活性剂的共聚物官能化以含有细胞类型特异或组织类型特异的靶向部分。