Analysis and purification method of edoxaban p-toluenesulfonate hydrate and preparation method of main impurities of edoxaban p-toluenesulfonate hydrate

The invention belongs to the technical field of medicines, and relates to an analysis and purification method of an edoxaban p-toluenesulfonate hydrate and a preparation method of main impurities of the edoxaban p-toluenesulfonate hydrate. N1, N2-bis (5-chloropyridine-2-yl) oxamide is a main impurit...

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Hauptverfasser:	YAN PINGQIU, JI HAIJIE, GAN LIXIN, TAO WEIFENG, LYU JIANGUO, HUANG GUOQUAN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY ORGANIC CHEMISTRY PHYSICS TESTING
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creator	YAN PINGQIU JI HAIJIE GAN LIXIN TAO WEIFENG LYU JIANGUO HUANG GUOQUAN
description	The invention belongs to the technical field of medicines, and relates to an analysis and purification method of an edoxaban p-toluenesulfonate hydrate and a preparation method of main impurities of the edoxaban p-toluenesulfonate hydrate. N1, N2-bis (5-chloropyridine-2-yl) oxamide is a main impurity generated in the synthesis process of the edoxaban p-toluenesulfonate hydrate. The preparation ofthe N1, N2-bis (5-chloropyridine 2-yl) oxamide provides a high-quality impurity reference substance for the edoxaban p-toluenesulfonate hydrate; The analysis method of the related substances of the edoxaban p-toluenesulfonate hydrate can effectively detect the N1, N2-bis (5-chloropyridine-2-yl) oxamide, meanwhile, the method is suitable for detection of other related substances, and guarantees thequality controllability of the edoxaban p-toluenesulfonate hydrate. The purification method of the edoxaban p-toluenesulfonate hydrate can effectively remove the impurity, namely, N1, N2-bis (5-chloropyridine 2-yl) oxamide ,
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N1, N2-bis (5-chloropyridine-2-yl) oxamide is a main impurity generated in the synthesis process of the edoxaban p-toluenesulfonate hydrate. The preparation ofthe N1, N2-bis (5-chloropyridine 2-yl) oxamide provides a high-quality impurity reference substance for the edoxaban p-toluenesulfonate hydrate; The analysis method of the related substances of the edoxaban p-toluenesulfonate hydrate can effectively detect the N1, N2-bis (5-chloropyridine-2-yl) oxamide, meanwhile, the method is suitable for detection of other related substances, and guarantees thequality controllability of the edoxaban p-toluenesulfonate hydrate. 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title	Analysis and purification method of edoxaban p-toluenesulfonate hydrate and preparation method of main impurities of edoxaban p-toluenesulfonate hydrate
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