Method for preparing perindopril tert-butylamine salt composition

The invention discloses a method for preparing a perindopril tert-butylamine salt composition. The method comprises the following steps of sieving and uniformly mixing perindopril tert-butylamine salt, magnesium stearate, sodium bicarbonate and part of excipient; uniformly mixing with the rest excipient; and carrying out tabletting and finally packaging. Through the process, related substances ofa perindopril tert-butylamine tablet can be effectively controlled, the safety and stability of the medicine are improved, and the process is convenient to operate and suitable for commercial production. 本发明公开了一种制备培哚普利叔丁胺盐组合物的方法，包括将培哚普利叔丁胺盐与硬脂酸镁、碳酸氢钠及部分赋形剂先过筛、混匀；再与剩余赋形剂混匀；压片，最后包装。通过以上工艺可有效控制培哚普利叔丁胺片的有关物质，提高药物的安全性和稳定性，且操作方便，适用于商业化生产。