COMPOUNDS FOR TREATMENT OF CARDIAC ARRHYTHMIAS AND HEART FAILURE
This disclosure concerns compounds and a method for modulating the activity of calcium ion channels, including Ca2+-induced (or Ca2+-activated) calcium release channels and conformationally coupled calcium release channels such as ryanodine receptors. Some of the compounds have a structure according...
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| creator | SIBRIAN-VAZQUEZ MARTHA BOATMAN DOUGLAS THAINASHMUTHU JOSEPHRAJAN |
| description | This disclosure concerns compounds and a method for modulating the activity of calcium ion channels, including Ca2+-induced (or Ca2+-activated) calcium release channels and conformationally coupled calcium release channels such as ryanodine receptors. Some of the compounds have a structure according to formula I, or a stereoisomer, tautomer, hydrate, solvate, prodrug, or pharmaceutically acceptable salt thereof.
本公开涉及用于调节钙离子通道的活性的化合物和方法，所述钙离子通道包括Ca2+诱导的(或Ca2+活化的)钙释放通道和构象偶联的钙释放通道，如兰尼碱受体。一些化合物具有式I的结构或其立体异构体、互变异构体、水合物、溶剂化物、前药或药物学可接受的盐。 |
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本公开涉及用于调节钙离子通道的活性的化合物和方法，所述钙离子通道包括Ca2+诱导的(或Ca2+活化的)钙释放通道和构象偶联的钙释放通道，如兰尼碱受体。一些化合物具有式I的结构或其立体异构体、互变异构体、水合物、溶剂化物、前药或药物学可接受的盐。</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20201113&DB=EPODOC&CC=CN&NR=111936466A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20201113&DB=EPODOC&CC=CN&NR=111936466A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SIBRIAN-VAZQUEZ MARTHA</creatorcontrib><creatorcontrib>BOATMAN DOUGLAS</creatorcontrib><creatorcontrib>THAINASHMUTHU JOSEPHRAJAN</creatorcontrib><title>COMPOUNDS FOR TREATMENT OF CARDIAC ARRHYTHMIAS AND HEART FAILURE</title><description>This disclosure concerns compounds and a method for modulating the activity of calcium ion channels, including Ca2+-induced (or Ca2+-activated) calcium release channels and conformationally coupled calcium release channels such as ryanodine receptors. Some of the compounds have a structure according to formula I, or a stereoisomer, tautomer, hydrate, solvate, prodrug, or pharmaceutically acceptable salt thereof.
本公开涉及用于调节钙离子通道的活性的化合物和方法，所述钙离子通道包括Ca2+诱导的(或Ca2+活化的)钙释放通道和构象偶联的钙释放通道，如兰尼碱受体。一些化合物具有式I的结构或其立体异构体、互变异构体、水合物、溶剂化物、前药或药物学可接受的盐。</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHBw9vcN8A_1cwlWcPMPUggJcnUM8XX1C1Hwd1Nwdgxy8XR0VnAMCvKIDPHw9XQMVnD0c1HwcHUMClFwc_T0CQ1y5WFgTUvMKU7lhdLcDIpuriHOHrqpBfnxqcUFicmpeakl8c5-hoaGlsZmJmZmjsbEqAEAp-0qmw</recordid><startdate>20201113</startdate><enddate>20201113</enddate><creator>SIBRIAN-VAZQUEZ MARTHA</creator><creator>BOATMAN DOUGLAS</creator><creator>THAINASHMUTHU JOSEPHRAJAN</creator><scope>EVB</scope></search><sort><creationdate>20201113</creationdate><title>COMPOUNDS FOR TREATMENT OF CARDIAC ARRHYTHMIAS AND HEART FAILURE</title><author>SIBRIAN-VAZQUEZ MARTHA ; BOATMAN DOUGLAS ; THAINASHMUTHU JOSEPHRAJAN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN111936466A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2020</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>SIBRIAN-VAZQUEZ MARTHA</creatorcontrib><creatorcontrib>BOATMAN DOUGLAS</creatorcontrib><creatorcontrib>THAINASHMUTHU JOSEPHRAJAN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SIBRIAN-VAZQUEZ MARTHA</au><au>BOATMAN DOUGLAS</au><au>THAINASHMUTHU JOSEPHRAJAN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>COMPOUNDS FOR TREATMENT OF CARDIAC ARRHYTHMIAS AND HEART FAILURE</title><date>2020-11-13</date><risdate>2020</risdate><abstract>This disclosure concerns compounds and a method for modulating the activity of calcium ion channels, including Ca2+-induced (or Ca2+-activated) calcium release channels and conformationally coupled calcium release channels such as ryanodine receptors. Some of the compounds have a structure according to formula I, or a stereoisomer, tautomer, hydrate, solvate, prodrug, or pharmaceutically acceptable salt thereof.
本公开涉及用于调节钙离子通道的活性的化合物和方法，所述钙离子通道包括Ca2+诱导的(或Ca2+活化的)钙释放通道和构象偶联的钙释放通道，如兰尼碱受体。一些化合物具有式I的结构或其立体异构体、互变异构体、水合物、溶剂化物、前药或药物学可接受的盐。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | COMPOUNDS FOR TREATMENT OF CARDIAC ARRHYTHMIAS AND HEART FAILURE |
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