CONTROLLED EXPRESSION OF TRANSGENES USING CLOSE-ENDED DNA (CEDNA) VECTORS
Provided herein are methods and constructs comprising close-ended DNA (ceDNA vectors) for maintaining or sustaining a level of transgene expression at a predetermined level or range for a predefined time, or increasing the level of transgene expression in a cell or a subject, where the transgene exp...
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| creator | CHIOCCO MATT SAMAYOA PHILLIP KERR DOUGLAS A STANTON MATTHEW G KOTIN ROBERT M ANGELINO MARK D |
| description | Provided herein are methods and constructs comprising close-ended DNA (ceDNA vectors) for maintaining or sustaining a level of transgene expression at a predetermined level or range for a predefined time, or increasing the level of transgene expression in a cell or a subject, where the transgene expression level can be modulated (e.g., increased) with one or more subsequent administrations (e.g.,a re-dose or a booster administration) after an initial priming administration. Provided are methods for personalizing gene therapy throughout an individuals' lifespan to express a transgene at a level that meets an individual's needs, by modulating expression levels of a transgene expressed by ceDNA vector incrementally, or in a step-by-step manner, with one or more administrations after an initial priming administration (e.g., at time 0), thereby enabling titration of the level of expression of the transgene to a desired predetermined expression level or to a desired expression level range.
本文提供了包含闭合端DNA的方法和构建体(ceDN |
| format | Patent |
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本文提供了包含闭合端DNA的方法和构建体(ceDN</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2020</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20201103&DB=EPODOC&CC=CN&NR=111886343A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76419</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20201103&DB=EPODOC&CC=CN&NR=111886343A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CHIOCCO MATT</creatorcontrib><creatorcontrib>SAMAYOA PHILLIP</creatorcontrib><creatorcontrib>KERR DOUGLAS A</creatorcontrib><creatorcontrib>STANTON MATTHEW G</creatorcontrib><creatorcontrib>KOTIN ROBERT M</creatorcontrib><creatorcontrib>ANGELINO MARK D</creatorcontrib><title>CONTROLLED EXPRESSION OF TRANSGENES USING CLOSE-ENDED DNA (CEDNA) VECTORS</title><description>Provided herein are methods and constructs comprising close-ended DNA (ceDNA vectors) for maintaining or sustaining a level of transgene expression at a predetermined level or range for a predefined time, or increasing the level of transgene expression in a cell or a subject, where the transgene expression level can be modulated (e.g., increased) with one or more subsequent administrations (e.g.,a re-dose or a booster administration) after an initial priming administration. Provided are methods for personalizing gene therapy throughout an individuals' lifespan to express a transgene at a level that meets an individual's needs, by modulating expression levels of a transgene expressed by ceDNA vector incrementally, or in a step-by-step manner, with one or more administrations after an initial priming administration (e.g., at time 0), thereby enabling titration of the level of expression of the transgene to a desired predetermined expression level or to a desired expression level range.
本文提供了包含闭合端DNA的方法和构建体(ceDN</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2020</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPB09vcLCfL38XF1UXCNCAhyDQ729PdT8HdTCAly9At2d_VzDVYIDfb0c1dw9vEPdtV19XMBKnXxc1TQcHYFUpoKYa7OIf5BwTwMrGmJOcWpvFCam0HRzTXE2UM3tSA_PrW4IDE5NS-1JN7Zz9DQ0MLCzNjE2NGYGDUAMB4s-Q</recordid><startdate>20201103</startdate><enddate>20201103</enddate><creator>CHIOCCO MATT</creator><creator>SAMAYOA PHILLIP</creator><creator>KERR DOUGLAS A</creator><creator>STANTON MATTHEW G</creator><creator>KOTIN ROBERT M</creator><creator>ANGELINO MARK D</creator><scope>EVB</scope></search><sort><creationdate>20201103</creationdate><title>CONTROLLED EXPRESSION OF TRANSGENES USING CLOSE-ENDED DNA (CEDNA) VECTORS</title><author>CHIOCCO MATT ; SAMAYOA PHILLIP ; KERR DOUGLAS A ; STANTON MATTHEW G ; KOTIN ROBERT M ; ANGELINO MARK D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN111886343A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2020</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>CHIOCCO MATT</creatorcontrib><creatorcontrib>SAMAYOA PHILLIP</creatorcontrib><creatorcontrib>KERR DOUGLAS A</creatorcontrib><creatorcontrib>STANTON MATTHEW G</creatorcontrib><creatorcontrib>KOTIN ROBERT M</creatorcontrib><creatorcontrib>ANGELINO MARK D</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CHIOCCO MATT</au><au>SAMAYOA PHILLIP</au><au>KERR DOUGLAS A</au><au>STANTON MATTHEW G</au><au>KOTIN ROBERT M</au><au>ANGELINO MARK D</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CONTROLLED EXPRESSION OF TRANSGENES USING CLOSE-ENDED DNA (CEDNA) VECTORS</title><date>2020-11-03</date><risdate>2020</risdate><abstract>Provided herein are methods and constructs comprising close-ended DNA (ceDNA vectors) for maintaining or sustaining a level of transgene expression at a predetermined level or range for a predefined time, or increasing the level of transgene expression in a cell or a subject, where the transgene expression level can be modulated (e.g., increased) with one or more subsequent administrations (e.g.,a re-dose or a booster administration) after an initial priming administration. Provided are methods for personalizing gene therapy throughout an individuals' lifespan to express a transgene at a level that meets an individual's needs, by modulating expression levels of a transgene expressed by ceDNA vector incrementally, or in a step-by-step manner, with one or more administrations after an initial priming administration (e.g., at time 0), thereby enabling titration of the level of expression of the transgene to a desired predetermined expression level or to a desired expression level range.
本文提供了包含闭合端DNA的方法和构建体(ceDN</abstract><oa>free_for_read</oa></addata></record> |
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| language | chi ; eng |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | CONTROLLED EXPRESSION OF TRANSGENES USING CLOSE-ENDED DNA (CEDNA) VECTORS |
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