4-chloro-2-(2-fluoro-4-methoxyphenyl)-6-methoxyquinazoline and synthesis method thereof

The invention belongs to the technical field of organic synthesis, and discloses 4-chloro-2-(2-fluoro-4-methoxyphenyl)-6-methoxyquinazoline and a synthesis method thereof. The synthesis method provided by the invention comprises the following steps of: taking 2-amino-5-methoxybenzoic acid as a raw material, carrying out amination, substitution and acylation reactions to prepare 4-chloro-2-(2-fluoro-4-methoxyphenyl)-6-methoxyquinazoline. The synthesis method is simple in synthesis path, low in cost and high in efficiency. 本发明属于有机合成技术领域，公开了一种4-氯-2-(2-氟-4-甲氧基苯基)-6-甲氧基喹唑啉及其合成方法。本发明提供的合成方法为：以2-氨基-5-甲氧基苯甲酸为原料，经氨基化、取代及酰化反应三步反应制备了4-氯-2-(2-氟-4-甲氧基苯基)-6-甲氧基喹唑啉。该合成方法合成路径简单，成本低，效率高。